Pathway
Sulfide oxidation to sulfate
While the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is localized to mitochondria and is highly conserved, pointing back to a time when life was immersed in sulfide-rich waters.
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The pathway for sulfide oxidation consists of five reactions, one of which, the sulfur transfer from thiosulfate to glutathione, is still to be characterized fully. A mutation in one enzyme has been identified that is associated with ethylmalonyl encephalopathy and where tissue sulfide is elevated.
REACT:R-HSA-1614517Reactome
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Sulfide oxidation to sulfate · Sources: Reactome
- ETHE1 participates in Sulfide oxidation to sulfateProteinReactome R-HSA-1614517Inferred only
- SLC25A10 participates in Sulfide oxidation to sulfateProteinReactome R-HSA-1614517Inferred only
- SQOR participates in Sulfide oxidation to sulfateProteinReactome R-HSA-1614517Inferred only
- SUOX participates in Sulfide oxidation to sulfateProteinReactome R-HSA-1614517Inferred only
- TST participates in Sulfide oxidation to sulfateProteinReactome R-HSA-1614517Inferred only
- TSTD1 participates in Sulfide oxidation to sulfateProteinReactome R-HSA-1614517Inferred only