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Proteins/UNIPROT:Q9NP59
Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma..
Function from UniProtKB (Q9NP59), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
105 statements
105 statements · 6 reference databases · Subject: SLC40A1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
iron(2+)+protoniron(2+)+proton
Transported by SLC11A1 or SLC11A2 or SLC40A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05987CC BY 4.0Reference data
Transported by HEPH or SLC40A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
7 names
Resolves to: SLC40A1
Transported by SLC40A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09197CC BY 4.0Reference data