Proteins/UNIPROT:Q8IZK6

MCOLN2

ProteinUNIPROT:Q8IZK6Mucolipin-2

Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel (By similarity)..

Function from UniProtKB (Q8IZK6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 3 reference databases · Subject: MCOLN2 · Sources: Hetionet, Reactome, Rhea

Order

MYL5 covaries with MCOLN2ProteinHetionet hetionet:covaries:255231-4636Inferred only
MCOLN2 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
MCOLN2 participates in Stimuli-sensing channelsPathwayReactome R-HSA-2672351Inferred only
MCOLN2 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
MCOLN2 participates in TRP channelsPathwayReactome R-HSA-3295583Inferred only
Ca(2+) is transported by MCOLN2CompoundRhea RHEA:29671Inferred only
iron(2+) is transported by MCOLN2CompoundRhea RHEA:28486Inferred only

Reactions

2 reactions

iron(2+)iron(2+)
Transported by SLC11A2 or MCOLN2 or SLC25A28 or SLC41A2 or MCOLN1 or SLC40A1 or SLC25A37
Reaction pageDirection not assertedBalanced
Rhea RHEA:28486CC BY 4.0Reference data
Ca(2+)Ca(2+)
Transported by ANO9 or HTR3E or TMEM150C or

Other names

2 names

Resolves to: MCOLN2

Also called: Transient receptor potential channel mucolipin 2TRPML2

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