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Proteins/UNIPROT:P43116

PTGER2

Protein·UNIPROT:P43116

Open in the graph

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Function from UniProtKB (P43116), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

24 statements

24 statements · 4 reference databases · Subject: PTGER2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ACYP1 covaries with PTGER2ProteinHetionet hetionet:covaries:5732-97Inferred only
EPOP covaries with PTGER2ProteinHetionet hetionet:covaries:100170841-5732Inferred only
LGALS4 covaries with PTGER2ProteinHetionet hetionet:covaries:3960-5732Inferred only
SNORC covaries with PTGER2ProteinHetionet hetionet:covaries:389084-5732Inferred only
PTGDS interacts with PTGER2ProteinHetionet hetionet:interacts:5730-5732Inferred only
PTGER2 interacts with PTGESProteinHetionet hetionet:interacts:5732-9536Inferred only
PTGER2 interacts with PTGFRProteinHetionet hetionet:interacts:5732-5737Inferred only
PTGER2 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
PTGER2 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
PTGER2 participates in Eicosanoid ligand-binding receptorsPathwayReactome R-HSA-391903Inferred only
PTGER2 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
PTGER2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only

Show the remaining 12

PTGER2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
PTGER2 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
PTGER2 participates in Ovarian infertilityPathwayWikiPathways WP34Inferred only
PTGER2 participates in Prostaglandin and leukotriene metabolism in senescence PathwayWikiPathways WP5122Inferred only
PTGER2 participates in Prostaglandin signalingPathwayWikiPathways WP5088Inferred only
PTGER2 participates in Prostaglandin synthesis and regulationPathwayWikiPathways WP98Inferred only
PTGER2 participates in Prostanoid ligand receptorsPathwayReactome R-HSA-391908Inferred only
PTGER2 participates in Relationship between inflammation COX 2 and EGFRPathwayWikiPathways WP4483Inferred only
PTGER2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PTGER2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
PTGER2 participates in Small ligand GPCRsPathwayWikiPathways WP247Inferred only
PTGER2 regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P43116|GO:0007204Inferred only

Other names

3 names

Resolves to: PTGER2

Also called: PGE receptor EP2 subtypePGE2 receptor EP2 subtypeProstanoid EP2 receptor

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