Proteins/UNIPROT:Q9NX46

ADPRS

ProteinUNIPROT:Q9NX46ADP-ribosylhydrolase ARH31 compound

ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers..

Function from UniProtKB (Q9NX46), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · substrate of

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

nicotinamideCompoundCHEBI:17154Inferred only8 paths8 endpoints

What the reference databases state

GenCC submitters' classifications

1 row

neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures has a germline basis in ADPRSDiseaseGenCC HGNC:21304|MONDO:0100095Inferred only

Statements

22 statements

22 statements · 7 reference databases · Subject: ADPRS · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways

Order

GRM6 covaries with ADPRSProteinHetionet hetionet:covaries:2916-54936Inferred only
NFKBID covaries with ADPRSProteinHetionet hetionet:covaries:54936-84807Inferred only
NPTXR covaries with ADPRSProteinHetionet hetionet:covaries:23467-54936Inferred only
SIPA1L3 covaries with ADPRSProteinHetionet hetionet:covaries:23094-54936Inferred only
THAP12 covaries with ADPRSProteinHetionet hetionet:covaries:54936-5612Inferred only
ADPRS is expressed in gingival epitheliumAnatomyBgee ENSG00000116863Inferred only
ADPRS is expressed in right fallopian tubeAnatomyBgee ENSG00000116863Inferred only
ADPRS interacts with FRA10AC1ProteinHetionet hetionet:interacts:118924-54936Inferred only
ADPRS interacts with HEXDProteinHetionet hetionet:interacts:284004-54936Inferred only
UBC interacts with ADPRSProteinHetionet hetionet:interacts:54936-7316Inferred only
ADPRS participates in Base excision repairPathwayWikiPathways WP4752Inferred only
ADPRS participates in Base Excision RepairPathwayReactome R-HSA-73884Inferred only

Show the remaining 10

ADPRS participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
ADPRS participates in POLB-Dependent Long Patch Base Excision RepairPathwayReactome R-HSA-110362Inferred only
ADPRS participates in Resolution of Abasic Sites (AP sites)PathwayReactome R-HSA-73933Inferred only
ADPRS participates in Resolution of AP sites via the multiple-nucleotide patch replacement pathwayPathwayReactome R-HSA-110373Inferred only
ADPRS regulates negative regulation of necroptotic processBiological processgene ontology Q9NX46|GO:0060546Inferred only
ADPRS requires the cofactor magnesium(2+)CompoundUniProt Q9NX46Inferred only
1''-O-acetyl-ADP-alpha-D-ribose is a substrate of ADPRSCompoundRhea RHEA:58112Inferred only
ADP-D-ribose is a substrate of ADPRSCompoundRhea RHEA:68792Inferred only
alpha-NAD(+) is a substrate of ADPRSCompoundRhea RHEA:68792Inferred only
nicotinamide is a substrate of ADPRSCompoundRhea RHEA:68792Inferred only

Reactions

4 reactions

[(1''->2')-ADP-alpha-D-ribose](n)+water[(1''->2')-ADP-alpha-D-ribose](n-1)+ADP-D-ribose
Catalysed by PARG or ADPRS
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52216CC BY 4.0Reference data
1''-O-acetyl-ADP-alpha-D-ribose+waterADP-D-ribose+acetate+hydron
Catalysed by ADPRS
Reaction pageLeft to rightBalanced

Other names

8 names

Resolves to: ADPRS

Also called: [Protein ADP-ribosylarginine] hydrolase-like protein 2[Protein ADP-ribosylserine] hydrolaseADP-ribose glycohydrolase ARH3ADP-ribosylhydrolase 3ADPRHL2ARH3O-acetyl-ADP-ribose deacetylase ARH3Poly(ADP-ribose) glycohydrolase ARH3

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