Proteins/UNIPROT:Q99880

H2BC13

ProteinUNIPROT:Q99880

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Function from UniProtKB (Q99880), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

152 statements

152 statements · 3 reference databases · Subject: H2BC13 · Sources: Hetionet, Reactome, WikiPathways

Order

H2BC13 interacts with CAND1ProteinHetionet hetionet:interacts:55832-8340Inferred only
H2BC13 interacts with CUL1ProteinHetionet hetionet:interacts:8340-8454Inferred only
ITGA4 interacts with H2BC13ProteinHetionet hetionet:interacts:3676-8340Inferred only
MYC interacts with H2BC13ProteinHetionet hetionet:interacts:4609-8340Inferred only
H2BC13 interacts with PCLAFProteinHetionet hetionet:interacts:8340-9768Inferred only
H2BC13 interacts with RNF20ProteinHetionet hetionet:interacts:56254-8340Inferred only
H2BC13 interacts with RNF40ProteinHetionet hetionet:interacts:8340-9810Inferred only
H2BC13 interacts with SIRT7ProteinHetionet hetionet:interacts:51547-8340Inferred only
UBC interacts with H2BC13ProteinHetionet hetionet:interacts:7316-8340Inferred only
H2BC13 participates in Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3PathwayReactome R-HSA-5625886Inferred only
H2BC13 participates in Activation of anterior HOX genes in hindbrain development during early embryogenesisPathwayReactome R-HSA-5617472Inferred only
H2BC13 participates in Activation of HOX genes during differentiationPathwayReactome R-HSA-5619507Inferred only

Show the remaining 140

H2BC13 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
H2BC13 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
H2BC13 participates in Amyloid fiber formationPathwayReactome R-HSA-977225Inferred only
H2BC13 participates in Assembly of the ORC complex at the origin of replicationPathwayReactome R-HSA-68616Inferred only
H2BC13 participates in Assembly of the pre-replicative complexPathwayReactome R-HSA-68867Inferred only
H2BC13 participates in ATP-dependent chromatin remodelersPathwayReactome R-HSA-9932444Inferred only
H2BC13 participates in B-WICH complex positively regulates rRNA expressionPathwayReactome R-HSA-5250924Inferred only
H2BC13 participates in Base Excision RepairPathwayReactome R-HSA-73884Inferred only
H2BC13 participates in Base-Excision Repair, AP Site FormationPathwayReactome R-HSA-73929Inferred only
H2BC13 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
H2BC13 participates in Cell Cycle CheckpointsPathwayReactome R-HSA-69620Inferred only
H2BC13 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
H2BC13 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
H2BC13 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
H2BC13 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
H2BC13 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
H2BC13 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
H2BC13 participates in Cellular SenescencePathwayReactome R-HSA-2559583Inferred only
H2BC13 participates in ChAHP complex assemblyPathwayReactome R-HSA-9940465Inferred only
H2BC13 participates in CHD chromatin remodelersPathwayReactome R-HSA-9937848Inferred only
H2BC13 participates in CHD1 and CHD2 subfamilyPathwayReactome R-HSA-9943411Inferred only
H2BC13 participates in CHD3, CHD4, CHD5 subfamilyPathwayReactome R-HSA-9943965Inferred only
H2BC13 participates in CHD6, CHD7, CHD8, CHD9 subfamilyPathwayReactome R-HSA-9943962Inferred only
H2BC13 participates in Chromatin modifications during the maternal to zygotic transition (MZT)PathwayReactome R-HSA-9821002Inferred only
H2BC13 participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
H2BC13 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
H2BC13 participates in Chromosome MaintenancePathwayReactome R-HSA-73886Inferred only
H2BC13 participates in Cleavage of the damaged purinePathwayReactome R-HSA-110331Inferred only
H2BC13 participates in Cleavage of the damaged pyrimidinePathwayReactome R-HSA-110329Inferred only
H2BC13 participates in Co-inhibition by PD-1PathwayReactome R-HSA-389948Inferred only
H2BC13 participates in Condensation of Prophase ChromosomesPathwayReactome R-HSA-2299718Inferred only
H2BC13 participates in Defective pyroptosisPathwayReactome R-HSA-9710421Inferred only
H2BC13 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
H2BC13 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
H2BC13 participates in Deposition of new CENPA-containing nucleosomes at the centromerePathwayReactome R-HSA-606279Inferred only
H2BC13 participates in DepurinationPathwayReactome R-HSA-73927Inferred only
H2BC13 participates in DepyrimidinationPathwayReactome R-HSA-73928Inferred only
H2BC13 participates in DeubiquitinationPathwayReactome R-HSA-5688426Inferred only
H2BC13 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
H2BC13 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
H2BC13 participates in Diseases of programmed cell deathPathwayReactome R-HSA-9645723Inferred only
H2BC13 participates in DNA Damage/Telomere Stress Induced SenescencePathwayReactome R-HSA-2559586Inferred only
H2BC13 participates in DNA Double Strand Break ResponsePathwayReactome R-HSA-5693606Inferred only
H2BC13 participates in DNA Double-Strand Break RepairPathwayReactome R-HSA-5693532Inferred only
H2BC13 participates in DNA methylationPathwayReactome R-HSA-5334118Inferred only
H2BC13 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
H2BC13 participates in DNA ReplicationPathwayReactome R-HSA-69306Inferred only
H2BC13 participates in DNA Replication Pre-InitiationPathwayReactome R-HSA-69002Inferred only
H2BC13 participates in E3 ubiquitin ligases ubiquitinate target proteinsPathwayReactome R-HSA-8866654Inferred only
H2BC13 participates in Epigenetic regulation by WDR5-containing histone modifying complexesPathwayReactome R-HSA-9917777Inferred only
H2BC13 participates in Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexesPathwayReactome R-HSA-9851695Inferred only
H2BC13 participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
H2BC13 participates in Epigenetic regulation of gene expression by MLL3 and MLL4 complexesPathwayReactome R-HSA-9818564Inferred only
H2BC13 participates in ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionPathwayReactome R-HSA-427389Inferred only
H2BC13 participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
H2BC13 participates in Estrogen-dependent gene expressionPathwayReactome R-HSA-9018519Inferred only
H2BC13 participates in Formation of the beta-catenin:TCF transactivating complexPathwayReactome R-HSA-201722Inferred only
H2BC13 participates in FXIIa activates plasma kallikrein-kinin systemPathwayReactome R-HSA-9970672Inferred only
H2BC13 participates in G2/M CheckpointsPathwayReactome R-HSA-69481Inferred only
H2BC13 participates in G2/M DNA damage checkpointPathwayReactome R-HSA-69473Inferred only
H2BC13 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
H2BC13 participates in Gene Silencing by RNAPathwayReactome R-HSA-211000Inferred only
H2BC13 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
H2BC13 participates in HATs acetylate histonesPathwayReactome R-HSA-3214847Inferred only
H2BC13 participates in HCMV Early EventsPathwayReactome R-HSA-9609690Inferred only
H2BC13 participates in HCMV InfectionPathwayReactome R-HSA-9609646Inferred only
H2BC13 participates in HCMV Late EventsPathwayReactome R-HSA-9610379Inferred only
H2BC13 participates in HDACs deacetylate histonesPathwayReactome R-HSA-3214815Inferred only
H2BC13 participates in HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)PathwayReactome R-HSA-5693567Inferred only
H2BC13 participates in Homology Directed RepairPathwayReactome R-HSA-5693538Inferred only
H2BC13 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
H2BC13 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
H2BC13 participates in Inhibition of DNA recombination at telomerePathwayReactome R-HSA-9670095Inferred only
H2BC13 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
H2BC13 participates in Interaction of NuRD complexes with transcription factorsPathwayReactome R-HSA-9940951Inferred only
H2BC13 participates in M PhasePathwayReactome R-HSA-68886Inferred only
H2BC13 participates in Maternal to zygotic transition (MZT)PathwayReactome R-HSA-9816359Inferred only
H2BC13 participates in MeiosisPathwayReactome R-HSA-1500620Inferred only
H2BC13 participates in Meiotic recombinationPathwayReactome R-HSA-912446Inferred only
H2BC13 participates in Meiotic synapsisPathwayReactome R-HSA-1221632Inferred only
H2BC13 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
H2BC13 participates in Mitotic ProphasePathwayReactome R-HSA-68875Inferred only
H2BC13 participates in MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosisPathwayReactome R-HSA-9841922Inferred only
H2BC13 participates in Negative epigenetic regulation of rRNA expressionPathwayReactome R-HSA-5250941Inferred only
H2BC13 participates in Negative Regulation of CDH1 Gene TranscriptionPathwayReactome R-HSA-9764725Inferred only
H2BC13 participates in Nonhomologous End-Joining (NHEJ)PathwayReactome R-HSA-5693571Inferred only
H2BC13 participates in NoRC negatively regulates rRNA expressionPathwayReactome R-HSA-427413Inferred only
H2BC13 participates in Nucleosome assemblyPathwayReactome R-HSA-774815Inferred only
H2BC13 participates in NuRD complex assemblyPathwayReactome R-HSA-9937850Inferred only
H2BC13 participates in Oxidative Stress Induced SenescencePathwayReactome R-HSA-2559580Inferred only
H2BC13 participates in Packaging Of Telomere EndsPathwayReactome R-HSA-171306Inferred only
H2BC13 participates in Positive epigenetic regulation of rRNA expressionPathwayReactome R-HSA-5250913Inferred only
H2BC13 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
H2BC13 participates in PRC2 methylates histones and DNAPathwayReactome R-HSA-212300Inferred only
H2BC13 participates in Pre-NOTCH Expression and ProcessingPathwayReactome R-HSA-1912422Inferred only
H2BC13 participates in Pre-NOTCH Transcription and TranslationPathwayReactome R-HSA-1912408Inferred only
H2BC13 participates in Processing of DNA double-strand break endsPathwayReactome R-HSA-5693607Inferred only
H2BC13 participates in Protein ubiquitinationPathwayReactome R-HSA-8852135Inferred only
H2BC13 participates in Recognition and association of DNA glycosylase with site containing an affected purinePathwayReactome R-HSA-110330Inferred only
H2BC13 participates in Recognition and association of DNA glycosylase with site containing an affected pyrimidinePathwayReactome R-HSA-110328Inferred only
H2BC13 participates in Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksPathwayReactome R-HSA-5693565Inferred only
H2BC13 participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only
H2BC13 participates in Regulation of CDH1 Gene TranscriptionPathwayReactome R-HSA-9764560Inferred only
H2BC13 participates in Regulation of endogenous retroelementsPathwayReactome R-HSA-9842860Inferred only
H2BC13 participates in Regulation of endogenous retroelements by KRAB-ZFP proteinsPathwayReactome R-HSA-9843940Inferred only
H2BC13 participates in Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)PathwayReactome R-HSA-9845323Inferred only
H2BC13 participates in Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complexPathwayReactome R-HSA-9843970Inferred only
H2BC13 participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
H2BC13 participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
H2BC13 participates in Regulation of PD-L1(CD274) expressionPathwayReactome R-HSA-9909648Inferred only
H2BC13 participates in Regulation of PD-L1(CD274) transcriptionPathwayReactome R-HSA-9909649Inferred only
H2BC13 participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
H2BC13 participates in Replacement of protamines by nucleosomes in the male pronucleusPathwayReactome R-HSA-9821993Inferred only
H2BC13 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
H2BC13 participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
H2BC13 participates in RHO GTPases activate PKNsPathwayReactome R-HSA-5625740Inferred only
H2BC13 participates in RNA Polymerase I Promoter EscapePathwayReactome R-HSA-73772Inferred only
H2BC13 participates in RNA Polymerase I Promoter OpeningPathwayReactome R-HSA-73728Inferred only
H2BC13 participates in RNA Polymerase I TranscriptionPathwayReactome R-HSA-73864Inferred only
H2BC13 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
H2BC13 participates in RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionPathwayReactome R-HSA-8936459Inferred only
H2BC13 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsPathwayReactome R-HSA-8939236Inferred only
H2BC13 participates in Senescence associated secretory phenotype SASP PathwayWikiPathways WP3391Inferred only
H2BC13 participates in Senescence-Associated Secretory Phenotype (SASP)PathwayReactome R-HSA-2559582Inferred only
H2BC13 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
H2BC13 participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
H2BC13 participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
H2BC13 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
H2BC13 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
H2BC13 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
H2BC13 participates in SIRT1 negatively regulates rRNA expressionPathwayReactome R-HSA-427359Inferred only
H2BC13 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
H2BC13 participates in Telomere end packaging and neurodevelopmental disordersPathwayWikiPathways WP5567Inferred only
H2BC13 participates in Telomere MaintenancePathwayReactome R-HSA-157579Inferred only
H2BC13 participates in Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex PathwayWikiPathways WP5565Inferred only
H2BC13 participates in Transcriptional regulation by RUNX1PathwayReactome R-HSA-8878171Inferred only
H2BC13 participates in Transcriptional regulation by small RNAsPathwayReactome R-HSA-5578749Inferred only
H2BC13 participates in Transcriptional regulation of granulopoiesisPathwayReactome R-HSA-9616222Inferred only
H2BC13 participates in Ub-specific processing proteasesPathwayReactome R-HSA-5689880Inferred only
H2BC13 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only

Other names

4 names

Resolves to: H2BC13

Also called: H2B/cH2BFCHIST1H2BLHistone H2B.c

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