Pathway
DNA Double Strand Break Response
DNA double-strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signaling, as well as proteins directly involved in the repair of DNA DSBs. For a recent review, please refer to Ciccia and Elledge, 2010.
REACT:R-HSA-5693606Reactome
What the reference databases state
Statements
97 statements
97 statements · 1 reference database · Subject: DNA Double Strand Break Response · Sources: Reactome
- ABL1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- ABRAXAS1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- ADRM1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- APBB1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- ATM participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- BABAM1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- BABAM2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- BAP1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- BARD1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- BAZ1B participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- BRCA1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- BRCC3 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
Show the remaining 85
- CHEK2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- CUL4A participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- CUL4B participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- DCAF8L2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- DDB1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- EYA1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- EYA2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- EYA3 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- EYA4 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2AX participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC11 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC12 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC13 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC14 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC15 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC17 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC21 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC26 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC3 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H2BC9 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H3-4 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- HERC2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- KAT5 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- KDM4A participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- KDM4B participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- KPNA2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- MAPK8 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- MDC1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- MRE11 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- NBN participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- NSD2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PHF6 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PIAS4 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PPP5C participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMA1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMA2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMA3 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMA4 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMA5 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMA6 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMA7 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMB1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMB2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMB3 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMB4 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMB5 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMB6 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMB7 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMC1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMC2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMC3 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMC4 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMC5 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMC6 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD11 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD12 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD13 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD14 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD3 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD6 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD7 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- PSMD8 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- RAD50 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- RBX1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- RNF168 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- RNF8 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- RPS27A participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- SEM1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- SMARCA5 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- SUMO1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- TP53 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- TP53BP1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UBA52 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UBB participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UBC participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UBE2I participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UBE2N participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UBE2V2 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UBXN1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only
- UIMC1 participates in DNA Double Strand Break ResponseProteinReactome R-HSA-5693606Inferred only