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Proteins/UNIPROT:Q9NYJ7

DLL3

Protein·UNIPROT:Q9NYJ7

Open in the graph

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity)..

Function from UniProtKB (Q9NYJ7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

autosomal recessive spondylocostal dysostosis has a germline basis in DLL3DiseaseGenCC HGNC:2909|MONDO:0010180Inferred only
spondylocostal dysostosis 1, autosomal recessive has a germline basis in DLL3DiseaseGenCC HGNC:2909|MONDO:0020692Inferred only

Statements

27 statements

27 statements · 4 reference databases · Subject: DLL3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

ARL4A covaries with DLL3ProteinHetionet hetionet:covaries:10124-10683Inferred only
DLL3 covaries with C11orf68ProteinHetionet hetionet:covaries:10683-83638Inferred only
GNG8 covaries with DLL3ProteinHetionet hetionet:covaries:10683-94235Inferred only
GPRIN1 covaries with DLL3ProteinHetionet hetionet:covaries:10683-114787Inferred only
DLL3 covaries with HOXB4ProteinHetionet hetionet:covaries:10683-3214Inferred only
DLL3 covaries with LEFTY1ProteinHetionet hetionet:covaries:10637-10683Inferred only
MAPK11 covaries with DLL3ProteinHetionet hetionet:covaries:10683-5600Inferred only
PGRMC1 covaries with DLL3ProteinHetionet hetionet:covaries:10683-10857Inferred only
DLL3 covaries with TGM5ProteinHetionet hetionet:covaries:10683-9333Inferred only
DLL3 covaries with THAP11ProteinHetionet hetionet:covaries:10683-57215Inferred only
WDR45 covaries with DLL3ProteinHetionet hetionet:covaries:10683-11152Inferred only
DLL3 covaries with WTIPProteinHetionet hetionet:covaries:10683-126374Inferred only

Show the remaining 15

DLL3 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
DLL3 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
DLL3 participates in Canonical and non canonical Notch signalingPathwayWikiPathways WP3845Inferred only
DLL3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
DLL3 participates in Epithelial to mesenchymal transition in colorectal cancerPathwayWikiPathways WP4239Inferred only
DLL3 participates in Formation of paraxial mesodermPathwayReactome R-HSA-9793380Inferred only
DLL3 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
DLL3 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
DLL3 participates in Notch signalingPathwayWikiPathways WP268Inferred only
DLL3 participates in Notch signalingPathwayWikiPathways WP61Inferred only
DLL3 participates in NOTCH1 regulation of endothelial cell calcificationPathwayWikiPathways WP3413Inferred only
DLL3 participates in Osteoblast differentiation and related diseasesPathwayWikiPathways WP4787Inferred only
DLL3 participates in SomitogenesisPathwayReactome R-HSA-9824272Inferred only
DLL3 participates in Somitogenesis in the context of spondylocostal dysostosisPathwayWikiPathways WP4785Inferred only
DLL3 regulates negative regulation of Notch signaling pathwayBiological processgene ontology Q9NYJ7|GO:0045746Inferred only

Other names

2 names

Resolves to: DLL3

Also called: Delta3Drosophila Delta homolog 3

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