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Proteins/UNIPROT:P10092

CALCB

Protein·UNIPROT:P10092

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CALCB/CGRP2 is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role..

Function from UniProtKB (P10092), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: CALCB · Sources: gene ontology, Hetionet, Reactome

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NR2F6 covaries with CALCBProteinHetionet hetionet:covaries:2063-797Inferred only
CALCB participates in Calcitonin-like ligand receptorsPathwayReactome R-HSA-419812Inferred only
CALCB participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
CALCB participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
CALCB participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CALCB participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CALCB participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CALCB participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CALCB regulates regulation of cytosolic calcium ion concentrationBiological processgene ontology P10092|GO:0051480Inferred only
GART increases the expression of CALCBProteinHetionet hetionet:regulates:2618-797Inferred only
MBNL1 increases the expression of CALCBProteinHetionet hetionet:regulates:4154-797Inferred only

Other names

6 names

Resolves to: CALCB

Also called: Beta-CGRPBeta-type CGRPCALC2Calcitonin gene-related peptide IICGRP-IICGRP2

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