Proteins/UNIPROT:Q13029

PRDM2

ProteinUNIPROT:Q13029PR domain zinc finger protein 2

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene..

Function from UniProtKB (Q13029), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 4 reference databases · Subject: PRDM2 · Sources: Bgee, gene ontology, Hetionet, WikiPathways

Order

ZNF70 covaries with PRDM2ProteinHetionet hetionet:covaries:7621-7799Inferred only
PRDM2 is expressed in buccal mucosa cellCell typeBgee ENSG00000116731Inferred only
PRDM2 is expressed in middle temporal gyrusAnatomyBgee ENSG00000116731Inferred only
PRDM2 is expressed in secondary oocyteCell typeBgee ENSG00000116731Inferred only
PRDM2 is expressed in sural nerveAnatomyBgee ENSG00000116731Inferred only
E2F1 interacts with PRDM2ProteinHetionet hetionet:interacts:1869-7799Inferred only
EP300 interacts with PRDM2ProteinHetionet hetionet:interacts:2033-7799Inferred only
ESR1 interacts with PRDM2ProteinHetionet hetionet:interacts:2099-7799Inferred only
PRDM2 interacts with H3-4ProteinHetionet hetionet:interacts:7799-8290Inferred only
PGR interacts with PRDM2ProteinHetionet hetionet:interacts:5241-7799Inferred only
RB1 interacts with PRDM2ProteinHetionet hetionet:interacts:5925-7799Inferred only
SRC interacts with PRDM2ProteinHetionet hetionet:interacts:6714-7799Inferred only

Show the remaining 11

TP53 interacts with PRDM2ProteinHetionet hetionet:interacts:7157-7799Inferred only
PRDM2 participates in Histone modificationsPathwayWikiPathways WP2369Inferred only
PRDM2 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q13029|GO:0000122Inferred only
PRDM2 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q13029|GO:0045944Inferred only
PRDM2 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q13029|GO:0006355Inferred only
PRDM2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q13029|GO:0006357Inferred only
BLMH increases the expression of PRDM2ProteinHetionet hetionet:regulates:642-7799Inferred only
FPGS decreases the expression of PRDM2ProteinHetionet hetionet:regulates:2356-7799Inferred only
MBNL1 increases the expression of PRDM2ProteinHetionet hetionet:regulates:4154-7799Inferred only
PIK3R1 increases the expression of PRDM2ProteinHetionet hetionet:regulates:5295-7799Inferred only
SMURF2 increases the expression of PRDM2ProteinHetionet hetionet:regulates:64750-7799Inferred only

Reactions

1 reaction

L-lysyl(9)-[histone H3]+3S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by PRDM2 or PRDM9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60276CC BY 4.0Reference data

Other names

9 names

Resolves to: PRDM2

Also called: GATA-3-binding protein G3BKMT8Lysine N-methyltransferase 8MTB-ZFMTE-binding proteinPR domain-containing protein 2Retinoblastoma protein-interacting zinc finger proteinRIZZinc finger protein RIZ

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