Proteins/UNIPROT:Q9H1C4

UNC93B1

ProteinUNIPROT:Q9H1C4

Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal..

Function from UniProtKB (Q9H1C4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

autoinflammatory syndrome has a germline basis in UNC93B1DiseaseGenCC HGNC:13481|MONDO:0019751Inferred only
herpes simplex encephalitis, susceptibility to, 1 has a germline basis in UNC93B1DiseaseGenCC HGNC:13481|MONDO:0024563Inferred only
systemic lupus erythematosus has a germline basis in UNC93B1DiseaseGenCC HGNC:13481|MONDO:0007915Inferred only

Statements

22 statements

22 statements · 3 reference databases · Subject: UNC93B1 · Sources: Hetionet, Reactome, WikiPathways

Order

BTBD17 covaries with UNC93B1ProteinHetionet hetionet:covaries:388419-81622Inferred only
GAS2L1 covaries with UNC93B1ProteinHetionet hetionet:covaries:10634-81622Inferred only
PSMD10 covaries with UNC93B1ProteinHetionet hetionet:covaries:5716-81622Inferred only
ZMYND10 covaries with UNC93B1ProteinHetionet hetionet:covaries:51364-81622Inferred only
CLPTM1 interacts with UNC93B1ProteinHetionet hetionet:interacts:1209-81622Inferred only
MBOAT7 interacts with UNC93B1ProteinHetionet hetionet:interacts:79143-81622Inferred only
SURF4 interacts with UNC93B1ProteinHetionet hetionet:interacts:6836-81622Inferred only
UBC interacts with UNC93B1ProteinHetionet hetionet:interacts:7316-81622Inferred only
UNC93B1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
UNC93B1 participates in Diseases associated with the TLR signaling cascadePathwayReactome R-HSA-5602358Inferred only
UNC93B1 participates in Diseases of Immune SystemPathwayReactome R-HSA-5260271Inferred only
UNC93B1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only

Show the remaining 10

UNC93B1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
UNC93B1 participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only
UNC93B1 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
UNC93B1 participates in Toll-like Receptor CascadesPathwayReactome R-HSA-168898Inferred only
UNC93B1 participates in Trafficking and processing of endosomal TLRPathwayReactome R-HSA-1679131Inferred only
UNC93B1 participates in UNC93B1 deficiency - HSEPathwayReactome R-HSA-5602415Inferred only
ALDH7A1 increases the expression of UNC93B1ProteinHetionet hetionet:regulates:501-81622Inferred only
CDK11B decreases the expression of UNC93B1ProteinHetionet hetionet:regulates:984-81622Inferred only
DUSP22 increases the expression of UNC93B1ProteinHetionet hetionet:regulates:56940-81622Inferred only
HNF4A increases the expression of UNC93B1ProteinHetionet hetionet:regulates:3172-81622Inferred only

Other names

4 names

Resolves to: UNC93B1

Also called: hUNC93B1Unc-93B1UNC93UNC93B

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