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Proteins/UNIPROT:Q8N2H9
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (By similarity)..
Function from UniProtKB (Q8N2H9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
49 statements
49 statements · 4 reference databases · Subject: PELI3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 name
Resolves to: PELI3