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Proteins/UNIPROT:Q9Y6Y9

LY96

Protein·UNIPROT:Q9Y6Y9

Open in the graph

Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS..

Function from UniProtKB (Q9Y6Y9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

56 statements

56 statements · 4 reference databases · Subject: LY96 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CALM1 interacts with LY96ProteinHetionet hetionet:interacts:23643-801Inferred only
CALM1 interacts with LY96ProteinHetionet hetionet:interacts:23643-808Inferred only
CALM1 interacts with LY96ProteinHetionet hetionet:interacts:23643-805Inferred only
CDKN2C interacts with LY96ProteinHetionet hetionet:interacts:1031-23643Inferred only
TLR2 interacts with LY96ProteinHetionet hetionet:interacts:23643-7097Inferred only
TLR4 interacts with LY96ProteinHetionet hetionet:interacts:23643-7099Inferred only
LY96 participates in Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)PathwayReactome R-HSA-936964Inferred only
LY96 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
LY96 participates in Antigen processing-Cross presentationPathwayReactome R-HSA-1236975Inferred only
LY96 participates in ApoptosisPathwayReactome R-HSA-109581Inferred only
LY96 participates in Caspase activation via Death Receptors in the presence of ligandPathwayReactome R-HSA-140534Inferred only
LY96 participates in Caspase activation via extrinsic apoptotic signalling pathwayPathwayReactome R-HSA-5357769Inferred only

Show the remaining 44

LY96 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
LY96 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
LY96 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
LY96 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
LY96 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
LY96 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
LY96 participates in Diseases associated with the TLR signaling cascadePathwayReactome R-HSA-5602358Inferred only
LY96 participates in Diseases of Immune SystemPathwayReactome R-HSA-5260271Inferred only
LY96 participates in ER-Phagosome pathwayPathwayReactome R-HSA-1236974Inferred only
LY96 participates in Fibrin complement receptor 3 signalingPathwayWikiPathways WP4136Inferred only
LY96 participates in Heme signalingPathwayReactome R-HSA-9707616Inferred only
LY96 participates in IKK complex recruitment mediated by RIP1PathwayReactome R-HSA-937041Inferred only
LY96 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
LY96 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
LY96 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
LY96 participates in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationPathwayReactome R-HSA-975163Inferred only
LY96 participates in IRAK4 deficiency (TLR2/4)PathwayReactome R-HSA-5603041Inferred only
LY96 participates in MyD88 deficiency (TLR2/4)PathwayReactome R-HSA-5602498Inferred only
LY96 participates in MyD88 dependent cascade initiated on endosomePathwayReactome R-HSA-975155Inferred only
LY96 participates in MyD88-independent TLR4 cascadePathwayReactome R-HSA-166166Inferred only
LY96 participates in MyD88:MAL(TIRAP) cascade initiated on plasma membranePathwayReactome R-HSA-166058Inferred only
LY96 participates in Pathogenic Escherichia coli infectionPathwayWikiPathways WP2272Inferred only
LY96 participates in Programmed Cell DeathPathwayReactome R-HSA-5357801Inferred only
LY96 participates in Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7PathwayReactome R-HSA-9824878Inferred only
LY96 participates in Regulation of TLR by endogenous ligandPathwayReactome R-HSA-5686938Inferred only
LY96 participates in Regulation of toll like receptor signalingPathwayWikiPathways WP1449Inferred only
LY96 participates in Respiratory syncytial virus (RSV) attachment and entryPathwayReactome R-HSA-9820960Inferred only
LY96 participates in Respiratory Syncytial Virus Infection PathwayPathwayReactome R-HSA-9820952Inferred only
LY96 participates in RSV-host interactionsPathwayReactome R-HSA-9833110Inferred only
LY96 participates in Toll Like Receptor 2 (TLR2) CascadePathwayReactome R-HSA-181438Inferred only
LY96 participates in Toll Like Receptor 4 (TLR4) CascadePathwayReactome R-HSA-166016Inferred only
LY96 participates in Toll Like Receptor 7/8 (TLR7/8) CascadePathwayReactome R-HSA-168181Inferred only
LY96 participates in Toll Like Receptor 9 (TLR9) CascadePathwayReactome R-HSA-168138Inferred only
LY96 participates in Toll like receptor signalingPathwayWikiPathways WP75Inferred only
LY96 participates in Toll Like Receptor TLR1:TLR2 CascadePathwayReactome R-HSA-168179Inferred only
LY96 participates in Toll Like Receptor TLR6:TLR2 CascadePathwayReactome R-HSA-168188Inferred only
LY96 participates in Toll-like Receptor CascadesPathwayReactome R-HSA-168898Inferred only
LY96 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationPathwayReactome R-HSA-975138Inferred only
LY96 participates in TRAF6-mediated induction of TAK1 complex within TLR4 complexPathwayReactome R-HSA-937072Inferred only
LY96 participates in TRIF (TICAM1)-mediated TLR4 signalingPathwayReactome R-HSA-937061Inferred only
LY96 participates in TRIF-mediated programmed cell deathPathwayReactome R-HSA-2562578Inferred only
LY96 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
LY96 regulates positive regulation of lipopolysaccharide-mediated signaling pathwayBiological processgene ontology Q9Y6Y9|GO:0031666Inferred only
LY96 regulates positive regulation of tumor necrosis factor productionBiological processgene ontology Q9Y6Y9|GO:0032760Inferred only

Other names

6 names

Resolves to: LY96

Also called: ESOP-1ESOP1Ly-96MD-2MD2Protein MD-2

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