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Proteins/UNIPROT:Q86WI3

NLRC5

Protein·UNIPROT:Q86WI3

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Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms..

Function from UniProtKB (Q86WI3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

37 statements

37 statements · 3 reference databases · Subject: NLRC5 · Sources: gene ontology, Hetionet, Reactome

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NLRC5 covaries with NME9ProteinHetionet hetionet:covaries:347736-84166Inferred only
NLRC5 covaries with ZMYM6ProteinHetionet hetionet:covaries:84166-9204Inferred only
CHUK interacts with NLRC5ProteinHetionet hetionet:interacts:1147-84166Inferred only
IKBKB interacts with NLRC5ProteinHetionet hetionet:interacts:3551-84166Inferred only
UBC interacts with NLRC5ProteinHetionet hetionet:interacts:7316-84166Inferred only
NLRC5 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
NLRC5 participates in DDX58/IFIH1-mediated induction of interferon-alpha/betaPathwayReactome R-HSA-168928Inferred only
NLRC5 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
NLRC5 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
NLRC5 participates in Interleukin-1 family signalingPathwayReactome R-HSA-446652Inferred only
NLRC5 participates in Interleukin-1 signalingPathwayReactome R-HSA-9020702Inferred only
NLRC5 participates in MyD88 cascade initiated on plasma membranePathwayReactome R-HSA-975871Inferred only

Show the remaining 25

NLRC5 participates in MyD88 dependent cascade initiated on endosomePathwayReactome R-HSA-975155Inferred only
NLRC5 participates in MyD88-independent TLR4 cascadePathwayReactome R-HSA-166166Inferred only
NLRC5 participates in MyD88:MAL(TIRAP) cascade initiated on plasma membranePathwayReactome R-HSA-166058Inferred only
NLRC5 participates in Negative regulators of DDX58/IFIH1 signalingPathwayReactome R-HSA-936440Inferred only
NLRC5 participates in Regulation of NF-kappa B signalingPathwayReactome R-HSA-9758274Inferred only
NLRC5 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
NLRC5 participates in TAK1-dependent IKK and NF-kappa-B activationPathwayReactome R-HSA-445989Inferred only
NLRC5 participates in Toll Like Receptor 10 (TLR10) CascadePathwayReactome R-HSA-168142Inferred only
NLRC5 participates in Toll Like Receptor 2 (TLR2) CascadePathwayReactome R-HSA-181438Inferred only
NLRC5 participates in Toll Like Receptor 3 (TLR3) CascadePathwayReactome R-HSA-168164Inferred only
NLRC5 participates in Toll Like Receptor 4 (TLR4) CascadePathwayReactome R-HSA-166016Inferred only
NLRC5 participates in Toll Like Receptor 5 (TLR5) CascadePathwayReactome R-HSA-168176Inferred only
NLRC5 participates in Toll Like Receptor 7/8 (TLR7/8) CascadePathwayReactome R-HSA-168181Inferred only
NLRC5 participates in Toll Like Receptor 9 (TLR9) CascadePathwayReactome R-HSA-168138Inferred only
NLRC5 participates in Toll Like Receptor TLR1:TLR2 CascadePathwayReactome R-HSA-168179Inferred only
NLRC5 participates in Toll Like Receptor TLR6:TLR2 CascadePathwayReactome R-HSA-168188Inferred only
NLRC5 participates in Toll-like Receptor CascadesPathwayReactome R-HSA-168898Inferred only
NLRC5 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationPathwayReactome R-HSA-975138Inferred only
NLRC5 participates in TRIF (TICAM1)-mediated TLR4 signalingPathwayReactome R-HSA-937061Inferred only
NLRC5 regulates negative regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q86WI3|GO:0043124Inferred only
NLRC5 regulates negative regulation of type I interferon-mediated signaling pathwayBiological processgene ontology Q86WI3|GO:0060339Inferred only
NLRC5 regulates positive regulation of MHC class I biosynthetic processBiological processgene ontology Q86WI3|GO:0045345Inferred only
NLRC5 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q86WI3|GO:0045944Inferred only
NLRC5 regulates positive regulation of type I interferon-mediated signaling pathwayBiological processgene ontology Q86WI3|GO:0060340Inferred only
NLRC5 regulates positive regulation of type II interferon-mediated signaling pathwayBiological processgene ontology Q86WI3|GO:0060335Inferred only

Other names

6 names

Resolves to: NLRC5

Also called: Caterpiller protein 16.1CLR16.1NOD27NOD4Nucleotide-binding oligomerization domain protein 27Nucleotide-binding oligomerization domain protein 4

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