Proteins/UNIPROT:Q9H1K0

RBSN

ProteinUNIPROT:Q9H1K0

Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane..

Function from UniProtKB (Q9H1K0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Kariminejad neurodevelopmental syndrome has a germline basis in RBSNDiseaseGenCC HGNC:20759|MONDO:0975795Inferred only

Statements

23 statements

23 statements · 3 reference databases · Subject: RBSN · Sources: gene ontology, Hetionet, Reactome

Order

RBSN covaries with B3GNT4ProteinHetionet hetionet:covaries:64145-79369Inferred only
ZNF577 covaries with RBSNProteinHetionet hetionet:covaries:64145-84765Inferred only
DISC1 interacts with RBSNProteinHetionet hetionet:interacts:27185-64145Inferred only
RBSN interacts with DTNBP1ProteinHetionet hetionet:interacts:64145-84062Inferred only
EHD1 interacts with RBSNProteinHetionet hetionet:interacts:10938-64145Inferred only
EHD2 interacts with RBSNProteinHetionet hetionet:interacts:30846-64145Inferred only
EHD3 interacts with RBSNProteinHetionet hetionet:interacts:30845-64145Inferred only
MAPK14 interacts with RBSNProteinHetionet hetionet:interacts:1432-64145Inferred only
RAB14 interacts with RBSNProteinHetionet hetionet:interacts:51552-64145Inferred only
RAB22A interacts with RBSNProteinHetionet hetionet:interacts:57403-64145Inferred only
RAB24 interacts with RBSNProteinHetionet hetionet:interacts:53917-64145Inferred only
RAB2A interacts with RBSNProteinHetionet hetionet:interacts:5862-64145Inferred only

Show the remaining 11

RAB4A interacts with RBSNProteinHetionet hetionet:interacts:5867-64145Inferred only
RAB5A interacts with RBSNProteinHetionet hetionet:interacts:5868-64145Inferred only
RAB5C interacts with RBSNProteinHetionet hetionet:interacts:5878-64145Inferred only
VPS45 interacts with RBSNProteinHetionet hetionet:interacts:11311-64145Inferred only
RBSN participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
RBSN participates in HemostasisPathwayReactome R-HSA-109582Inferred only
RBSN participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
RBSN participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
RBSN participates in Toll Like Receptor 9 (TLR9) CascadePathwayReactome R-HSA-168138Inferred only
RBSN participates in Toll-like Receptor CascadesPathwayReactome R-HSA-168898Inferred only
RBSN regulates regulation of Golgi organizationBiological processgene ontology Q9H1K0|GO:1903358Inferred only

Other names

5 names

Resolves to: RBSN

Also called: 110 kDa proteinFYVE finger-containing Rab5 effector protein rabenosyn-5RAB effector RBSNZFYVE20Zinc finger FYVE domain-containing protein 20

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