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Proteins/UNIPROT:Q9HCT0

FGF22

Protein·UNIPROT:Q9HCT0

Open in the graph

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development..

Function from UniProtKB (Q9HCT0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

56 statements

56 statements · 4 reference databases · Subject: FGF22 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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FGFBP1 interacts with FGF22ProteinHetionet hetionet:interacts:27006-9982Inferred only
FGF22 participates in Activated point mutants of FGFR2PathwayReactome R-HSA-2033519Inferred only
FGF22 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
FGF22 participates in Constitutive Signaling by Aberrant PI3K in CancerPathwayReactome R-HSA-2219530Inferred only
FGF22 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
FGF22 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
FGF22 participates in Downstream signaling of activated FGFR1PathwayReactome R-HSA-5654687Inferred only
FGF22 participates in Downstream signaling of activated FGFR2PathwayReactome R-HSA-5654696Inferred only
FGF22 participates in Embryonic stem cell pluripotency pathwaysPathwayWikiPathways WP3931Inferred only
FGF22 participates in FGFR1 ligand binding and activationPathwayReactome R-HSA-190242Inferred only
FGF22 participates in FGFR1b ligand binding and activationPathwayReactome R-HSA-190370Inferred only
FGF22 participates in FGFR2 ligand binding and activationPathwayReactome R-HSA-190241Inferred only

Show the remaining 44

FGF22 participates in FGFR2 mutant receptor activationPathwayReactome R-HSA-1839126Inferred only
FGF22 participates in FGFR2b ligand binding and activationPathwayReactome R-HSA-190377Inferred only
FGF22 participates in FGFRL1 modulation of FGFR1 signalingPathwayReactome R-HSA-5658623Inferred only
FGF22 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
FGF22 participates in FRS-mediated FGFR1 signalingPathwayReactome R-HSA-5654693Inferred only
FGF22 participates in FRS-mediated FGFR2 signalingPathwayReactome R-HSA-5654700Inferred only
FGF22 participates in IGF1R signaling cascadePathwayReactome R-HSA-2428924Inferred only
FGF22 participates in Insulin receptor signalling cascadePathwayReactome R-HSA-74751Inferred only
FGF22 participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
FGF22 participates in IRS-mediated signallingPathwayReactome R-HSA-112399Inferred only
FGF22 participates in IRS-related events triggered by IGF1RPathwayReactome R-HSA-2428928Inferred only
FGF22 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
FGF22 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
FGF22 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
FGF22 participates in Negative regulation of FGFR1 signalingPathwayReactome R-HSA-5654726Inferred only
FGF22 participates in Negative regulation of FGFR2 signalingPathwayReactome R-HSA-5654727Inferred only
FGF22 participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
FGF22 participates in Phospholipase C-mediated cascade; FGFR2PathwayReactome R-HSA-5654221Inferred only
FGF22 participates in Phospholipase C-mediated cascade: FGFR1PathwayReactome R-HSA-5654219Inferred only
FGF22 participates in PI-3K cascade:FGFR1PathwayReactome R-HSA-5654689Inferred only
FGF22 participates in PI-3K cascade:FGFR2PathwayReactome R-HSA-5654695Inferred only
FGF22 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
FGF22 participates in PI3K CascadePathwayReactome R-HSA-109704Inferred only
FGF22 participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
FGF22 participates in PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPathwayReactome R-HSA-6811558Inferred only
FGF22 participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
FGF22 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
FGF22 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
FGF22 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
FGF22 participates in SHC-mediated cascade:FGFR1PathwayReactome R-HSA-5654688Inferred only
FGF22 participates in SHC-mediated cascade:FGFR2PathwayReactome R-HSA-5654699Inferred only
FGF22 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FGF22 participates in Signaling by FGFRPathwayReactome R-HSA-190236Inferred only
FGF22 participates in Signaling by FGFR in diseasePathwayReactome R-HSA-1226099Inferred only
FGF22 participates in Signaling by FGFR1PathwayReactome R-HSA-5654736Inferred only
FGF22 participates in Signaling by FGFR2PathwayReactome R-HSA-5654738Inferred only
FGF22 participates in Signaling by FGFR2 in diseasePathwayReactome R-HSA-5655253Inferred only
FGF22 participates in Signaling by Insulin receptorPathwayReactome R-HSA-74752Inferred only
FGF22 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
FGF22 participates in Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)PathwayReactome R-HSA-2404192Inferred only
FGF22 regulates positive regulation of cell population proliferationBiological processgene ontology Q9HCT0|GO:0008284Inferred only
FGF22 regulates positive regulation of MAPK cascadeBiological processgene ontology Q9HCT0|GO:0043410Inferred only
FGF22 regulates regulation of cell migrationBiological processgene ontology Q9HCT0|GO:0030334Inferred only
FGF22 regulates regulation of synapse maturationBiological processgene ontology Q9HCT0|GO:0090128Inferred only

Other names

2 names

Resolves to: FGF22

Also called: FGF-22Fibroblast growth factor 22

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