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Proteins/UNIPROT:P35070

BTC

Protein·UNIPROT:P35070

Open in the graph

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells..

Function from UniProtKB (P35070), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

58 statements

58 statements · 4 reference databases · Subject: BTC · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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BTC interacts with EGFRProteinHetionet hetionet:interacts:1956-685Inferred only
BTC interacts with ERBB4ProteinHetionet hetionet:interacts:2066-685Inferred only
BTC interacts with MMP9ProteinHetionet hetionet:interacts:4318-685Inferred only
BTC interacts with S100A4ProteinHetionet hetionet:interacts:6275-685Inferred only
BTC participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
BTC participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
BTC participates in Constitutive Signaling by Aberrant PI3K in CancerPathwayReactome R-HSA-2219530Inferred only
BTC participates in DiseasePathwayReactome R-HSA-1643685Inferred only
BTC participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
BTC participates in Downregulation of ERBB2 signalingPathwayReactome R-HSA-8863795Inferred only
BTC participates in EGFR downregulationPathwayReactome R-HSA-182971Inferred only
BTC participates in EGFR interacts with phospholipase C-gammaPathwayReactome R-HSA-212718Inferred only

Show the remaining 46

BTC participates in ErbB signalingPathwayWikiPathways WP673Inferred only
BTC participates in ERBB2 Activates PTK6 SignalingPathwayReactome R-HSA-8847993Inferred only
BTC participates in ERBB2 Regulates Cell MotilityPathwayReactome R-HSA-6785631Inferred only
BTC participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
BTC participates in Estrogen-dependent nuclear events downstream of ESR-membrane signalingPathwayReactome R-HSA-9634638Inferred only
BTC participates in Extra-nuclear estrogen signalingPathwayReactome R-HSA-9009391Inferred only
BTC participates in GAB1 signalosomePathwayReactome R-HSA-180292Inferred only
BTC participates in GRB2 events in EGFR signalingPathwayReactome R-HSA-179812Inferred only
BTC participates in GRB2 events in ERBB2 signalingPathwayReactome R-HSA-1963640Inferred only
BTC participates in Inhibition of Signaling by Overexpressed EGFRPathwayReactome R-HSA-5638303Inferred only
BTC participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
BTC participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
BTC participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
BTC participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
BTC participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
BTC participates in Nuclear signaling by ERBB4PathwayReactome R-HSA-1251985Inferred only
BTC participates in PI3K events in ERBB2 signalingPathwayReactome R-HSA-1963642Inferred only
BTC participates in PI3K events in ERBB4 signalingPathwayReactome R-HSA-1250342Inferred only
BTC participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
BTC participates in PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPathwayReactome R-HSA-6811558Inferred only
BTC participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
BTC participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
BTC participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
BTC participates in SHC1 events in EGFR signalingPathwayReactome R-HSA-180336Inferred only
BTC participates in SHC1 events in ERBB2 signalingPathwayReactome R-HSA-1250196Inferred only
BTC participates in SHC1 events in ERBB4 signalingPathwayReactome R-HSA-1250347Inferred only
BTC participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
BTC participates in Signaling by EGFRPathwayReactome R-HSA-177929Inferred only
BTC participates in Signaling by EGFR in CancerPathwayReactome R-HSA-1643713Inferred only
BTC participates in Signaling by ERBB2PathwayReactome R-HSA-1227986Inferred only
BTC participates in Signaling by ERBB2 in CancerPathwayReactome R-HSA-1227990Inferred only
BTC participates in Signaling by ERBB2 KD MutantsPathwayReactome R-HSA-9664565Inferred only
BTC participates in Signaling by ERBB2 TMD/JMD mutantsPathwayReactome R-HSA-9665686Inferred only
BTC participates in Signaling by ERBB4PathwayReactome R-HSA-1236394Inferred only
BTC participates in Signaling by Non-Receptor Tyrosine KinasesPathwayReactome R-HSA-9006927Inferred only
BTC participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
BTC participates in Signaling by Overexpressed Wild-Type EGFR in CancerPathwayReactome R-HSA-5638302Inferred only
BTC participates in Signaling by PTK6PathwayReactome R-HSA-8848021Inferred only
BTC participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
BTC participates in Tyrosine kinase inhibitors in glioblastomaPathwayWikiPathways WP5494Inferred only
BTC participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
BTC regulates positive regulation of cell differentiationBiological processgene ontology P35070|GO:0045597Inferred only
BTC regulates positive regulation of cell population proliferationBiological processgene ontology P35070|GO:0008284Inferred only
BTC regulates positive regulation of fibroblast proliferationBiological processgene ontology P35070|GO:0048146Inferred only
BTC regulates positive regulation of mitotic nuclear divisionBiological processgene ontology P35070|GO:0045840Inferred only
BTC regulates positive regulation of urine volumeBiological processgene ontology P35070|GO:0035810Inferred only

Other names

1 name

Resolves to: BTC

Also called: Probetacellulin [Cleaved into: Betacellulin

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