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Proteins/UNIPROT:Q86Z14

KLB

Protein·UNIPROT:Q86Z14

Open in the graph

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity)..

Function from UniProtKB (Q86Z14), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

hypogonadotropic hypogonadism has a germline basis in KLBDiseaseGenCC HGNC:15527|MONDO:0018555Inferred only

Statements

36 statements

36 statements · 3 reference databases · Subject: KLB · Sources: Hetionet, Reactome, WikiPathways

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KLB covaries with SPHK2ProteinHetionet hetionet:covaries:152831-56848Inferred only
KLB covaries with USHBP1ProteinHetionet hetionet:covaries:152831-83878Inferred only
FGF21 interacts with KLBProteinHetionet hetionet:interacts:152831-26291Inferred only
FGFR1 interacts with KLBProteinHetionet hetionet:interacts:152831-2260Inferred only
KLB participates in betaKlotho-mediated ligand bindingPathwayReactome R-HSA-1307965Inferred only
KLB participates in Constitutive Signaling by Aberrant PI3K in CancerPathwayReactome R-HSA-2219530Inferred only
KLB participates in DiseasePathwayReactome R-HSA-1643685Inferred only
KLB participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
KLB participates in Downstream signaling of activated FGFR4PathwayReactome R-HSA-5654716Inferred only
KLB participates in FGFR4 ligand binding and activationPathwayReactome R-HSA-190322Inferred only
KLB participates in FRS-mediated FGFR4 signalingPathwayReactome R-HSA-5654712Inferred only
KLB participates in IGF1R signaling cascadePathwayReactome R-HSA-2428924Inferred only

Show the remaining 24

KLB participates in Insulin receptor signalling cascadePathwayReactome R-HSA-74751Inferred only
KLB participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
KLB participates in IRS-mediated signallingPathwayReactome R-HSA-112399Inferred only
KLB participates in IRS-related events triggered by IGF1RPathwayReactome R-HSA-2428928Inferred only
KLB participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
KLB participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
KLB participates in Negative regulation of FGFR4 signalingPathwayReactome R-HSA-5654733Inferred only
KLB participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
KLB participates in Phospholipase C-mediated cascade; FGFR4PathwayReactome R-HSA-5654228Inferred only
KLB participates in PI-3K cascade:FGFR4PathwayReactome R-HSA-5654720Inferred only
KLB participates in PI3K CascadePathwayReactome R-HSA-109704Inferred only
KLB participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
KLB participates in PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPathwayReactome R-HSA-6811558Inferred only
KLB participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
KLB participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
KLB participates in SHC-mediated cascade:FGFR4PathwayReactome R-HSA-5654719Inferred only
KLB participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
KLB participates in Signaling by FGFRPathwayReactome R-HSA-190236Inferred only
KLB participates in Signaling by FGFR4PathwayReactome R-HSA-5654743Inferred only
KLB participates in Signaling by Insulin receptorPathwayReactome R-HSA-74752Inferred only
KLB participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
KLB participates in Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)PathwayReactome R-HSA-2404192Inferred only
KLB participates in ThermogenesisPathwayWikiPathways WP4321Inferred only
KLB participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only

Other names

3 names

Resolves to: KLB

Also called: BetaKlothoBKLKlotho beta-like protein

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