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Proteins/UNIPROT:Q8WWG1

NRG4

Protein·UNIPROT:Q8WWG1

Open in the graph

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity)..

Function from UniProtKB (Q8WWG1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

34 statements

34 statements · 3 reference databases · Subject: NRG4 · Sources: Hetionet, Reactome, WikiPathways

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CFAP47 covaries with NRG4ProteinHetionet hetionet:covaries:145957-286464Inferred only
ZNF157 covaries with NRG4ProteinHetionet hetionet:covaries:145957-7712Inferred only
ERBB4 interacts with NRG4ProteinHetionet hetionet:interacts:145957-2066Inferred only
FATE1 interacts with NRG4ProteinHetionet hetionet:interacts:145957-89885Inferred only
NRG4 participates in Constitutive Signaling by Aberrant PI3K in CancerPathwayReactome R-HSA-2219530Inferred only
NRG4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
NRG4 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
NRG4 participates in Downregulation of ERBB2 signalingPathwayReactome R-HSA-8863795Inferred only
NRG4 participates in ErbB signalingPathwayWikiPathways WP673Inferred only
NRG4 participates in ERBB2 Activates PTK6 SignalingPathwayReactome R-HSA-8847993Inferred only
NRG4 participates in ERBB2 Regulates Cell MotilityPathwayReactome R-HSA-6785631Inferred only
NRG4 participates in GRB2 events in ERBB2 signalingPathwayReactome R-HSA-1963640Inferred only

Show the remaining 22

NRG4 participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
NRG4 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
NRG4 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
NRG4 participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
NRG4 participates in Nuclear signaling by ERBB4PathwayReactome R-HSA-1251985Inferred only
NRG4 participates in PI3K events in ERBB2 signalingPathwayReactome R-HSA-1963642Inferred only
NRG4 participates in PI3K events in ERBB4 signalingPathwayReactome R-HSA-1250342Inferred only
NRG4 participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
NRG4 participates in PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPathwayReactome R-HSA-6811558Inferred only
NRG4 participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
NRG4 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
NRG4 participates in SHC1 events in ERBB2 signalingPathwayReactome R-HSA-1250196Inferred only
NRG4 participates in SHC1 events in ERBB4 signalingPathwayReactome R-HSA-1250347Inferred only
NRG4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NRG4 participates in Signaling by ERBB2PathwayReactome R-HSA-1227986Inferred only
NRG4 participates in Signaling by ERBB2 in CancerPathwayReactome R-HSA-1227990Inferred only
NRG4 participates in Signaling by ERBB2 KD MutantsPathwayReactome R-HSA-9664565Inferred only
NRG4 participates in Signaling by ERBB2 TMD/JMD mutantsPathwayReactome R-HSA-9665686Inferred only
NRG4 participates in Signaling by ERBB4PathwayReactome R-HSA-1236394Inferred only
NRG4 participates in Signaling by Non-Receptor Tyrosine KinasesPathwayReactome R-HSA-9006927Inferred only
NRG4 participates in Signaling by PTK6PathwayReactome R-HSA-8848021Inferred only
NRG4 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only

Other names

3 names

Resolves to: NRG4

Also called: [Cleaved into: Neuregulin-4NRG-4Pro-NRG4

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