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Proteins/UNIPROT:O75935

DCTN3

Protein·UNIPROT:O75935

Open in the graph

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis..

Function from UniProtKB (O75935), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

53 statements

53 statements · 3 reference databases · Subject: DCTN3 · Sources: Hetionet, Reactome, WikiPathways

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DCTN3 covaries with SPRED3ProteinHetionet hetionet:covaries:11258-399473Inferred only
ATXN1 interacts with DCTN3ProteinHetionet hetionet:interacts:11258-6310Inferred only
DCTN1 interacts with DCTN3ProteinHetionet hetionet:interacts:11258-1639Inferred only
GSK3B interacts with DCTN3ProteinHetionet hetionet:interacts:11258-2932Inferred only
PBX2 interacts with DCTN3ProteinHetionet hetionet:interacts:11258-5089Inferred only
DCTN3 participates in 17p13 3 YWHAE copy number variationPathwayWikiPathways WP5376Inferred only
DCTN3 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
DCTN3 participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
DCTN3 participates in Anchoring of the basal body to the plasma membranePathwayReactome R-HSA-5620912Inferred only
DCTN3 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
DCTN3 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
DCTN3 participates in AURKA Activation by TPX2PathwayReactome R-HSA-8854518Inferred only

Show the remaining 41

DCTN3 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
DCTN3 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
DCTN3 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
DCTN3 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
DCTN3 participates in Centrosome maturationPathwayReactome R-HSA-380287Inferred only
DCTN3 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
DCTN3 participates in COPI-independent Golgi-to-ER retrograde trafficPathwayReactome R-HSA-6811436Inferred only
DCTN3 participates in COPI-mediated anterograde transportPathwayReactome R-HSA-6807878Inferred only
DCTN3 participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
DCTN3 participates in G2/M TransitionPathwayReactome R-HSA-69275Inferred only
DCTN3 participates in Golgi-to-ER retrograde transportPathwayReactome R-HSA-8856688Inferred only
DCTN3 participates in HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligandPathwayReactome R-HSA-3371497Inferred only
DCTN3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
DCTN3 participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
DCTN3 participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
DCTN3 participates in Loss of Nlp from mitotic centrosomesPathwayReactome R-HSA-380259Inferred only
DCTN3 participates in Loss of proteins required for interphase microtubule organization from the centrosomePathwayReactome R-HSA-380284Inferred only
DCTN3 participates in M PhasePathwayReactome R-HSA-68886Inferred only
DCTN3 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
DCTN3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
DCTN3 participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
DCTN3 participates in Mitotic G2-G2/M phasesPathwayReactome R-HSA-453274Inferred only
DCTN3 participates in Mitotic PrometaphasePathwayReactome R-HSA-68877Inferred only
DCTN3 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
DCTN3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DCTN3 participates in Processing of antigen in germinal center B cellsPathwayReactome R-HSA-9979719Inferred only
DCTN3 participates in Recruitment of mitotic centrosome proteins and complexesPathwayReactome R-HSA-380270Inferred only
DCTN3 participates in Recruitment of NuMA to mitotic centrosomesPathwayReactome R-HSA-380320Inferred only
DCTN3 participates in Regulation of PLK1 Activity at G2/M TransitionPathwayReactome R-HSA-2565942Inferred only
DCTN3 participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
DCTN3 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
AURKA decreases the expression of DCTN3ProteinHetionet hetionet:regulates:6790-11258Inferred only
CASC3 decreases the expression of DCTN3ProteinHetionet hetionet:regulates:22794-11258Inferred only
ERG decreases the expression of DCTN3ProteinHetionet hetionet:regulates:2078-11258Inferred only
FUT1 decreases the expression of DCTN3ProteinHetionet hetionet:regulates:2523-11258Inferred only
GSTZ1 increases the expression of DCTN3ProteinHetionet hetionet:regulates:2954-11258Inferred only
MELK decreases the expression of DCTN3ProteinHetionet hetionet:regulates:9833-11258Inferred only
NTRK3 decreases the expression of DCTN3ProteinHetionet hetionet:regulates:4916-11258Inferred only
PFAS decreases the expression of DCTN3ProteinHetionet hetionet:regulates:5198-11258Inferred only
RAB4A decreases the expression of DCTN3ProteinHetionet hetionet:regulates:5867-11258Inferred only
TOP1 decreases the expression of DCTN3ProteinHetionet hetionet:regulates:7150-11258Inferred only

Other names

3 names

Resolves to: DCTN3

Also called: DCTN22Dynactin complex subunit 22 kDa subunitp22

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