Proteins/UNIPROT:Q96FN5

KIF12

ProteinUNIPROT:Q96FN5

Involved in the negative regulation of fatty acid biosynthesis, probably acting as an adapter that allows ubiquitination of acetyl-CoA carboxylase 1 (ACACA) by E3 ubiquitin-protein ligase COP1, and promotes ACACA degradation. The adapter function requires the C-terminal proline-rich domain and may be apart from the kinesin motor activity (Probable)..

Function from UniProtKB (Q96FN5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

cholestasis has a germline basis in KIF12DiseaseGenCC HGNC:21495|MONDO:0001751Inferred only
cholestasis, progressive familial intrahepatic, 8 has a germline basis in KIF12DiseaseGenCC HGNC:21495|MONDO:0030505Inferred only

Statements

20 statements

20 statements · 3 reference databases · Subject: KIF12 · Sources: gene ontology, Hetionet, Reactome

Order

KIF12 covaries with CENPEProteinHetionet hetionet:covaries:1062-113220Inferred only
KIF12 covaries with CHST6ProteinHetionet hetionet:covaries:113220-4166Inferred only
KIF12 covaries with FADDProteinHetionet hetionet:covaries:113220-8772Inferred only
OR4Q3 covaries with KIF12ProteinHetionet hetionet:covaries:113220-441669Inferred only
KIF12 covaries with PRSS58ProteinHetionet hetionet:covaries:113220-136541Inferred only
KIF12 covaries with SLC44A5ProteinHetionet hetionet:covaries:113220-204962Inferred only
KIF12 covaries with VPS13AProteinHetionet hetionet:covaries:113220-23230Inferred only
KIF12 covaries with ZNF10ProteinHetionet hetionet:covaries:113220-7556Inferred only
KIF12 covaries with ZNF197ProteinHetionet hetionet:covaries:10168-113220Inferred only
KIF12 covaries with ZNF26ProteinHetionet hetionet:covaries:113220-7574Inferred only
KIF12 covaries with ZNF660ProteinHetionet hetionet:covaries:113220-285349Inferred only
KIF12 participates in COPI-dependent Golgi-to-ER retrograde trafficPathwayReactome R-HSA-6811434Inferred only

Show the remaining 8

KIF12 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
KIF12 participates in Golgi-to-ER retrograde transportPathwayReactome R-HSA-8856688Inferred only
KIF12 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
KIF12 participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
KIF12 participates in KinesinsPathwayReactome R-HSA-983189Inferred only
KIF12 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
KIF12 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
KIF12 regulates negative regulation of fatty acid biosynthetic processBiological processgene ontology Q96FN5|GO:0045717Inferred only

Other names

1 name

Resolves to: KIF12

Also called: Kinesin-like protein KIF12

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