Proteins/UNIPROT:Q8NDV7

TNRC6A

ProteinUNIPROT:Q8NDV7

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes..

Function from UniProtKB (Q8NDV7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

83 statements

83 statements · 3 reference databases · Subject: TNRC6A · Sources: gene ontology, Hetionet, Reactome

Order

TMEM35A covaries with TNRC6AProteinHetionet hetionet:covaries:27327-59353Inferred only
ZNF317 covaries with TNRC6AProteinHetionet hetionet:covaries:27327-57693Inferred only
ZNF550 covaries with TNRC6AProteinHetionet hetionet:covaries:162972-27327Inferred only
AGO1 interacts with TNRC6AProteinHetionet hetionet:interacts:26523-27327Inferred only
AGO2 interacts with TNRC6AProteinHetionet hetionet:interacts:27161-27327Inferred only
TNRC6A interacts with AGO3ProteinHetionet hetionet:interacts:192669-27327Inferred only
TNRC6A interacts with AGO4ProteinHetionet hetionet:interacts:192670-27327Inferred only
CUL3 interacts with TNRC6AProteinHetionet hetionet:interacts:27327-8452Inferred only
PABPC1 interacts with TNRC6AProteinHetionet hetionet:interacts:26986-27327Inferred only
UBC interacts with TNRC6AProteinHetionet hetionet:interacts:27327-7316Inferred only
UBE2I interacts with TNRC6AProteinHetionet hetionet:interacts:27327-7329Inferred only
TNRC6A interacts with WNK1ProteinHetionet hetionet:interacts:27327-65125Inferred only

Show the remaining 71

TNRC6A participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
TNRC6A participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
TNRC6A participates in Assembly of the 9+2 motile ciliaPathwayReactome R-HSA-9975924Inferred only
TNRC6A participates in Beta-catenin independent WNT signalingPathwayReactome R-HSA-3858494Inferred only
TNRC6A participates in Ca2+ pathwayPathwayReactome R-HSA-4086398Inferred only
TNRC6A participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
TNRC6A participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
TNRC6A participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
TNRC6A participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
TNRC6A participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
TNRC6A participates in Cellular SenescencePathwayReactome R-HSA-2559583Inferred only
TNRC6A participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
TNRC6A participates in Co-inhibition by PD-1PathwayReactome R-HSA-389948Inferred only
TNRC6A participates in Competing endogenous RNAs (ceRNAs) regulate PTEN translationPathwayReactome R-HSA-8948700Inferred only
TNRC6A participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
TNRC6A participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
TNRC6A participates in Estrogen-dependent gene expressionPathwayReactome R-HSA-9018519Inferred only
TNRC6A participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
TNRC6A participates in Gene Silencing by RNAPathwayReactome R-HSA-211000Inferred only
TNRC6A participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
TNRC6A participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TNRC6A participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
TNRC6A participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
TNRC6A participates in MAPK6/MAPK4 signalingPathwayReactome R-HSA-5687128Inferred only
TNRC6A participates in MITF-M-dependent gene expressionPathwayReactome R-HSA-9856651Inferred only
TNRC6A participates in MITF-M-regulated melanocyte developmentPathwayReactome R-HSA-9730414Inferred only
TNRC6A participates in MTOR signallingPathwayReactome R-HSA-165159Inferred only
TNRC6A participates in NR1H2 and NR1H3-mediated signalingPathwayReactome R-HSA-9024446Inferred only
TNRC6A participates in NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and effluxPathwayReactome R-HSA-9029569Inferred only
TNRC6A participates in Oncogene Induced SenescencePathwayReactome R-HSA-2559585Inferred only
TNRC6A participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
TNRC6A participates in Oxidative Stress Induced SenescencePathwayReactome R-HSA-2559580Inferred only
TNRC6A participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
TNRC6A participates in Post-transcriptional silencing by small RNAsPathwayReactome R-HSA-426496Inferred only
TNRC6A participates in Pre-NOTCH Expression and ProcessingPathwayReactome R-HSA-1912422Inferred only
TNRC6A participates in Pre-NOTCH Transcription and TranslationPathwayReactome R-HSA-1912408Inferred only
TNRC6A participates in PTEN RegulationPathwayReactome R-HSA-6807070Inferred only
TNRC6A participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only
TNRC6A participates in Regulation of CDH1 mRNA translation by microRNAsPathwayReactome R-HSA-9764562Inferred only
TNRC6A participates in Regulation of CDH11 Expression and FunctionPathwayReactome R-HSA-9759475Inferred only
TNRC6A participates in Regulation of CDH11 mRNA translation by microRNAsPathwayReactome R-HSA-9759811Inferred only
TNRC6A participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
TNRC6A participates in Regulation of Expression and Function of Type II Classical CadherinsPathwayReactome R-HSA-9764260Inferred only
TNRC6A participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
TNRC6A participates in Regulation of MECP2 expression and activityPathwayReactome R-HSA-9022692Inferred only
TNRC6A participates in Regulation of MITF-M-dependent genes involved in apoptosisPathwayReactome R-HSA-9824594Inferred only
TNRC6A participates in Regulation of NPAS4 gene expressionPathwayReactome R-HSA-9768759Inferred only
TNRC6A participates in Regulation of NPAS4 mRNA translationPathwayReactome R-HSA-9768778Inferred only
TNRC6A participates in Regulation of PD-L1(CD274) expressionPathwayReactome R-HSA-9909648Inferred only
TNRC6A participates in Regulation of PD-L1(CD274) translationPathwayReactome R-HSA-9909620Inferred only
TNRC6A participates in Regulation of PTEN mRNA translationPathwayReactome R-HSA-8943723Inferred only
TNRC6A participates in Regulation of RUNX1 Expression and ActivityPathwayReactome R-HSA-8934593Inferred only
TNRC6A participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
TNRC6A participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
TNRC6A participates in RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionPathwayReactome R-HSA-8936459Inferred only
TNRC6A participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TNRC6A participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
TNRC6A participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
TNRC6A participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
TNRC6A participates in Signaling by TGFBR3PathwayReactome R-HSA-9839373Inferred only
TNRC6A participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
TNRC6A participates in TGFBR3 expressionPathwayReactome R-HSA-9839394Inferred only
TNRC6A participates in TP53 Regulates Metabolic GenesPathwayReactome R-HSA-5628897Inferred only
TNRC6A participates in Transcriptional Regulation by MECP2PathwayReactome R-HSA-8986944Inferred only
TNRC6A participates in Transcriptional Regulation by NPAS4PathwayReactome R-HSA-9634815Inferred only
TNRC6A participates in Transcriptional regulation by RUNX1PathwayReactome R-HSA-8878171Inferred only
TNRC6A participates in Transcriptional regulation by small RNAsPathwayReactome R-HSA-5578749Inferred only
TNRC6A participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
TNRC6A participates in Transcriptional Regulation by VENTXPathwayReactome R-HSA-8853884Inferred only
TNRC6A participates in Transcriptional regulation of multiciliogenesisPathwayReactome R-HSA-9945556Inferred only
TNRC6A regulates positive regulation of nuclear-transcribed mRNA poly(A) tail shorteningBiological processgene ontology Q8NDV7|GO:0060213Inferred only

Other names

9 names

Resolves to: TNRC6A

Also called: CAG repeat protein 26CAGH26EMSY interactor proteinGlycine-tryptophan protein of 182 kDaGW1GW182 autoantigenKIAA1460Protein GW1TNRC6

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