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Proteins/UNIPROT:Q9NZQ7
Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis..
The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity)..
Function from UniProtKB (Q9NZQ7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · inhibits
1 compound
1 compound.
0 reported routes1 assembled route
38 statements
38 statements · 4 reference databases · Subject: CD274 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 paper
11 names
Resolves to: CD274