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Proteins/UNIPROT:Q9Y2A9

B3GNT3

Protein·UNIPROT:Q9Y2A9N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

Open in the graph

Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans..

Function from UniProtKB (Q9Y2A9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

69 statements

69 statements · 4 reference databases · Subject: B3GNT3 · Sources: Human Protein Atlas, Human-GEM, Reactome, Rhea

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B3GNT3 is expressed in colonAnatomyHuman Protein Atlas ENSG00000179913Inferred only
B3GNT3 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000179913Inferred only
B3GNT3 is expressed in placentaAnatomyHuman Protein Atlas ENSG00000179913Inferred only
B3GNT3 is expressed in rectumAnatomyHuman Protein Atlas ENSG00000179913Inferred only
B3GNT3 is expressed in saliva-secreting glandAnatomyHuman Protein Atlas ENSG00000179913Inferred only
B3GNT3 is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000179913Inferred only
B3GNT3 is expressed in urinary bladderAnatomyHuman Protein Atlas ENSG00000179913Inferred only
B3GNT3 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
B3GNT3 participates in Co-inhibition by PD-1PathwayReactome R-HSA-389948Inferred only
B3GNT3 participates in Glycosaminoglycan metabolismPathwayReactome R-HSA-1630316Inferred only
B3GNT3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
B3GNT3 participates in Keratan sulfate biosynthesisPathwayReactome R-HSA-2022854Inferred only

Show the remaining 57

B3GNT3 participates in Keratan sulfate/keratin metabolismPathwayReactome R-HSA-1638074Inferred only
B3GNT3 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
B3GNT3 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
B3GNT3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
B3GNT3 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
B3GNT3 participates in O-linked glycosylation of mucinsPathwayReactome R-HSA-913709Inferred only
B3GNT3 participates in PD-L1(CD274) glycosylation and translocation to plasma membranePathwayReactome R-HSA-9931295Inferred only
B3GNT3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
B3GNT3 participates in Regulation of PD-L1(CD274) expressionPathwayReactome R-HSA-9909648Inferred only
B3GNT3 participates in Regulation of PD-L1(CD274) Post-translational modificationPathwayReactome R-HSA-9909615Inferred only
B3GNT3 participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of B3GNT3CompoundRhea RHEA:14389Inferred only
a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) is a substrate of B3GNT3CompoundHuman-GEM MAR08277Inferred only
a globoside Gb4Cer (d18:1(4E)) is a substrate of B3GNT3CompoundHuman-GEM MAR08194Inferred only
a neolactoside nLc4Cer(d18:1(4E)) is a substrate of B3GNT3CompoundHuman-GEM MAR00889Inferred only
an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of B3GNT3CompoundRhea RHEA:14389Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07475Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07473Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07449Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07446Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07444Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07368Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07365Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07362Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07359Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07356Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07353Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07350Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07347Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07344Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07341Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07338Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07336Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR00889Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR00891Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR08151Inferred only
CHEBI:16264 is a substrate of B3GNT3CompoundHuman-GEM MAR07478Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08147Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR00081Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR00082Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR00765Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR00892Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR00926Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08250Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08251Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08277Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08279Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08285Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08293Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08306Inferred only
CHEBI:67119 is a substrate of B3GNT3CompoundHuman-GEM MAR08317Inferred only
D-glucosyl-N-acylsphingosine is a substrate of B3GNT3CompoundHuman-GEM MAR00926Inferred only
D-glucosyl-N-acylsphingosine is a substrate of B3GNT3CompoundHuman-GEM MAR00765Inferred only
D-glucosyl-N-acylsphingosine is a substrate of B3GNT3CompoundHuman-GEM MAR08147Inferred only
UDP-N-acetyl-alpha-D-glucosamine is a substrate of B3GNT3CompoundRhea RHEA:56220Inferred only
UDP-N-acetyl-alpha-D-glucosamine is a substrate of B3GNT3CompoundRhea RHEA:56224Inferred only
UDP-N-acetyl-alpha-D-glucosamine is a substrate of B3GNT3CompoundRhea RHEA:14389Inferred only

Reactions

39 reactions

MAM02593g+CHEBI:67119proton+MAM02594g+UDP
Catalysed by B3GNT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00081CC BY 4.0Reference data
MAM01880g+CHEBI:67119proton+UDP+MAM03584g
Catalysed by B3GNT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus

Other names

19 names

Resolves to: B3GNT3

Also called: b3Gal-T8B3GALT8Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferaseBeta-1,3-galactosyltransferase 8Beta-1,3-GalTase 8Beta-1,3-Gn-T3Beta-1,3-N-acetylglucosaminyltransferase 3Beta-3-Gx-T8Beta3Gal-T8Beta3GalT8Beta3Gn-T3BGnT-3Core 1 extending beta-1,3-N-acetylglucosaminyltransferaseCore1-beta3GlcNAcTTMEM3Transmembrane protein 3

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Human-GEM MAR00082CC BY 4.0Reference data

D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP

Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum

Human-GEM MAR00765CC BY 4.0Reference data

a neolactoside nLc4Cer(d18:1(4E))+CHEBI:16264proton+MAM02593c+UDP

Catalysed by B3GNT2 or B3GNT4 or B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.149, 2.4.1.-cytosol

Human-GEM MAR00889CC BY 4.0Reference data

MAM02594c+CHEBI:16264proton+MAM02595c+UDP

Catalysed by B3GNT2 or B4GAT1 or B3GNT4 or B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.149, 2.4.1.-cytosol

Human-GEM MAR00891CC BY 4.0Reference data

MAM02595c+CHEBI:67119proton+MAM02596c+UDP

Catalysed by B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol

Human-GEM MAR00892CC BY 4.0Reference data

D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP

Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 12 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol

Human-GEM MAR00926CC BY 4.0Reference data

MAM02201g+CHEBI:16264proton+MAM02212g+UDP

Catalysed by B3GNT7 or B3GNT2 or B4GAT1 or B3GNT4 or B3GNT8 or B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus

Human-GEM MAR07336CC BY 4.0Reference data

MAM02223g+CHEBI:16264proton+MAM02231g+UDP

Catalysed by B3GNT7 or B3GNT2 or B4GAT1 or B3GNT4 or B3GNT8 or B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus

Human-GEM MAR07338CC BY 4.0Reference data

MAM02233g+CHEBI:16264proton+MAM02234g+UDP

Catalysed by B3GNT7 or B3GNT2 or B4GAT1 or B3GNT4 or B3GNT8 or B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus

Human-GEM MAR07341CC BY 4.0Reference data

MAM02236g+CHEBI:16264proton+MAM02202g+UDP

Catalysed by B3GNT7 or B3GNT2 or B4GAT1 or B3GNT4 or B3GNT8 or B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus

Human-GEM MAR07344CC BY 4.0Reference data

MAM02204g+CHEBI:16264proton+MAM02205g+UDP

Catalysed by B3GNT7 or B3GNT2 or B4GAT1 or B3GNT4 or B3GNT8 or B3GNT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus

Human-GEM MAR07347CC BY 4.0Reference data

Show the remaining 27

UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3