a 3-oxoacyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

412 compounds within 3 steps: 2 in 1, 75 in 2, 335 in 3

Three steps

a 2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 5 moreOne of 2 routes
a 2-acyl-sn-glycero-3-phospho-L-serineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA
3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 6 moreOne of 2 routes
N-docosanoylsphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 3 morecytosol
N-eicosanoylsphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 3 morecytosol
N-(octadecanoyl)-sphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 6 morecytosol
N-hexadecanoylsphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 5 more
N-(tetradecanoyl)-sphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
an N-acylsphinganine-1-phosphocholineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. sphingosine N-acyltransferase (sphinganine)
3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 8 morecytosolOne of 2 routes
3-oxohexadecasphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
3-oxotetradecasphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
3-oxooctadecanoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 7 morecytosolOne of 2 routes
(2E)-octadecenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
3. Carnitine O-Palmitoyltransferase
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 7 moremitochondrial matrix, cytosolOne of 10 routes
3-oxodocosanoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 7 morecytosolOne of 3 routes
3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
(8Z,11Z,14Z)-eicosatrienoateReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. Dihomo-gamma-linolenoyl-CoA hydrolase
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 5 morecytosol
1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
3. 1-acylglycerol-3-phosphate pool formation and breakdown
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 4 moremitochondrial matrix, cytosolOne of 3 routes
1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
3. 1-acylglycerol-3-phosphate pool formation and breakdown
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 4 moremitochondrial matrix, cytosolOne of 2 routes
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
N-octadecanoylsphing-4-enineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 4 morecytosol
N-eicosanoyl-sphing-4-enineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
N-tetracosanoyl-sphing-4-enineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 3 morecytosol
an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 7 more
a 1-O-alkylglycerone 3-phosphateReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. Acyl-CoA:glycerone-phosphate O-acyltransferase
3. alkylglycerone phosphate synthase (acylglycerone-phosphate)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol, peroxisomeOne of 2 routes
(9Z,12Z)-octadecadien-1-olReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
3-oxooctacosanyol-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
3-oxotetracosanoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 7 morecytosolOne of 3 routes
3-oxohexacosanoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. very-long-chain 3-oxoacyl-CoA synthase ((15Z)-tetracosenoyl-CoA)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 7 morecytosolOne of 3 routes
1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol
(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 4 morecytosol
(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 4 morecytosol
3-oxo-(13Z)-docosenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
3-oxo-(15Z)-tetracosenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (13Z)-docosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z)-tetracosenoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
2-hydroxyoctadecanoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
N-(15Z-tetracosenoyl)-sphinganineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
N-tetracosanoyl-heptadecasphing-4-enineReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. heptadecasphing-4-enine + tetracosanoyl-CoA = N-tetracosanoyl-heptadecasphing-4-enine + CoA + H(+)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
(2E)-hexacosenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. acyl-CoA oxidase (hexacosanoyl-CoA)
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol, peroxisomeOne of 2 routes
3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol
3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoAReach from here →
1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
2. acyl-CoA pool formation and breakdown
3. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol