N-eicosanoyl-sphing-4-enine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

132 compounds within 3 steps: 2 in 1, 17 in 2, 113 in 3

Three steps

2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACER2, PAFAH2, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by ACER2, PAFAH2, PLA2G15One of 2 routes
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACER2, PAFAH2, PLA2G15One of 3 routes
2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ACER2, PAFAH2, PLA2G15
2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ACER2, PAFAH2, PLA2G15
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACER2, PAFAH2, PLA2G15One of 3 routes
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACER2, PAFAH2, PLA2G15
2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ACER2, PAFAH2, PLA2G15
2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ACER2, PAFAH2, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ACER2, PAFAH2, PLA2G15
beta-D-glucosyl-N-dodecanoylsphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
3. beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by ACER2, NAAA, ASAH1, ASAH2 and 1 more
beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by ACER2, ACER1, ASAH2, GBA1
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine
Catalysed by ACER2, PAFAH2, PLA2G15
(11Z,14Z)-eicosadienoateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACER2cytosol, extracellular spaceOne of 12 routes
(17Z)-hexacosenoateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACER2cytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACER2cytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACER2cytosol, extracellular spaceOne of 12 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
Catalysed by ACER2, PAFAH2, PLA2G15
1-O-hexadecyl-sn-glycero-3-phosphateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
Catalysed by ACER2, PAFAH2, ENPP2, GDPD3 and 1 more
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACER2cytosol, extracellular spaceOne of 12 routes
hexadecanoateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
3. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
Catalysed by ACER2, CERS6, TLCD3B, CERS5 and 4 more
tricosanoateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACER2cytosol, extracellular spaceOne of 12 routes
1,2-dihexadecanoyl-sn-glycerolReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by ACER2, CERS1, CERS6, CERS3 and 4 more
1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by ACER2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by ACER2, CERS1, CERS6, CERS3 and 5 more
1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by ACER2, PAFAH2, PLA2G15
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by ACER2, PAFAH2, PLA2G15One of 8 routes
O-eicosanoyl-(R)-carnitineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
Catalysed by ACER2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
Catalysed by ACER2, CERS6, TLCD3B, CERS5 and 2 more
beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enineReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
Catalysed by ACER2, CERS1, TLCD3B, CERS2 and 2 more
N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)
Catalysed by ACER2, PAFAH2, CERK
N-eicosanoylglycinateReach from here →
1. N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enine
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by ACER2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol