deoxycholate

Three steps

• nonadecanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 morecytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Activation of dodecanedioic acid

  Catalysed by SLC27A2, SLC27A5, BAATcytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Production of Sebacoylcarnitine

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Production of Suberylcarnitine

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by SLC27A2, SLC27A5, BAATcytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SLC27A2, SLC27A5, BAAT, CRAT and 1 morecytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by SLC27A2, SLC27A5, BAAT, ACAA1 and 3 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Production of Hexadecanedioylcarnitine

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 morecytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. fatty-acid-CoA ligase

  Catalysed by SLC27A2, SLC27A5, BAATcytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSM4 and 5 morecytosolOne of 3 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX2, GPX4cytosol, inner side of the membrane, outer side of the membrane

• (5Z)-tetradecenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by SLC27A2, SLC27A5, BAAT, ACADM and 3 morecytosol, mitochondrial matrix

• N-tetradecanoylglycineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by GLYATL2cytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by SLC27A2, SLC27A5, BAAT, HADHA and 2 morecytosol, mitochondrial matrix

• N-eicosanoylglycinateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by BAATcytosol

• N-docosanoylglycineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by BAATcytosol

• N-hexacosanoylglycineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by BAATcytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 4 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, PTGES, MGST3, GPX1 and 3 morecytosol, inner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• an S-substituted glutathioneReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by ABCC4, GSTT4, GSTA4, GSTZ1 and 20 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GSTA1, GPX2 and 1 morecytosol, inner side of the membrane, outer side of the membrane

• taurochenodeoxycholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4cytosol, inner side of the membrane, outer side of the membrane