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A reference for what the literature reports. Not medical advice.

Reach

a triacylglycerol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

399 compounds within 3 steps: 7 in 1, 50 in 2, 342 in 3

Does it reach a compound?

Two steps

(17Z)-hexacosenoateReach from here →
1. triacylglycerol acylhydrolase
2. (10Z)-heptadecenoic acid formation
Catalysed by LPLextracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. triacylglycerol acylhydrolase
2. (10Z)-heptadecenoic acid formation
Catalysed by LPLextracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. triacylglycerol acylhydrolase
2. (10Z)-heptadecenoic acid formation
Catalysed by LPLextracellular spaceOne of 12 routes
a 1,3-diacyl-sn-glycerolReach from here →
1. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
2. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
Catalysed by DDHD2, LPL, LIPF, ABHD2 and 16 more
a fatty acyl-CoAReach from here →
1. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
Catalysed by DDHD2, LPL, LIPF, ABHD2 and 16 more
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. triacylglycerol acylhydrolase
2. (10Z)-heptadecenoic acid formation
Catalysed by LPLextracellular spaceOne of 12 routes
tricosanoateReach from here →
1. triacylglycerol acylhydrolase
2. (10Z)-heptadecenoic acid formation
Catalysed by LPLextracellular spaceOne of 12 routes

Three steps

(S)-carnitineReach from here →
Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosolOne of 260 routes
CHEBI:12947Reach from here →

Page 2 of 8

Catalysed by LPL, SGMS1, SGMS2, UGT8

extracellular space, cytosol

One of 5 routes

AReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

Catalysed by LPL, PTGS1, PTGS2extracellular spaceOne of 12 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP2C8, CYP2C9, CYP2C19 and 2 moreextracellular space

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP1A1, CYP2C8, CYP2D6 and 4 moreextracellular space

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP2C9, CYP2J2extracellular space

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP1A1, CYP2D6, CYP2C9 and 3 moreextracellular space

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
unspecific monooxygenase (arachidonate)

Catalysed by LPL, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
unspecific monooxygenase (arachidonate)

Catalysed by LPL, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP1A1extracellular space

21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
DHA[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate[r]

Catalysed by LPL, CYP2E1extracellular space, endoplasmic reticulumOne of 3 routes

13-hydroxytetradecanoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
myristic acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 13-hydroxytetradecanoate[r]

Catalysed by LPL, CYP2E1extracellular space, endoplasmic reticulumOne of 3 routes

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Catalysed by LPL, PTGS2extracellular space

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by LPL, PTGS2extracellular space

all-trans-3,4-didehydroretinolReach from here →

a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
carboxylesterase (retinyl-ester)
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3,4-didehydroretinol + 2 oxidized [adrenodoxin] + 2 H2O

Catalysed by PNPLA4, PNPLA2, CES2, RBP4 and 17 morecytosol

all-trans-4-hydroxyretinolReach from here →

a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
carboxylesterase (retinyl-ester)
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-4-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

Catalysed by PNPLA4, PNPLA2, CES2, RBP4 and 17 morecytosol

prostaglandin G1Reach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

Catalysed by LPL, PTGS2extracellular space

prostaglandin G3Reach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3

Catalysed by LPL, PTGS2extracellular space

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP3A4, CYP2C9extracellular space

(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate

Catalysed by LPL, ALOX5, ALOX15extracellular space

14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate

Catalysed by LPL, ALOX15extracellular space

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by LPL, ALOX15extracellular space

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by LPL, ALOX15extracellular space

19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP4F8, CYP4F12extracellular space

2,4-dinitrophenyl-S-glutathioneReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
transport of arachidonate (cytosol to extracellular)

Catalysed by LPL, SLCO1B1extracellular space, cytosolOne of 2 routes

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

Catalysed by LPL, PM20D1extracellular space

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by LPL, PM20D1extracellular space

N-(9Z-octadecenoyl)-L-leucineReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by LPL, PM20D1extracellular space

(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP1A1, CYP1A2, CYP3A4 and 4 moreextracellular space

(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP1A1, CYP3A4, CYP2C8 and 3 moreextracellular space

8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP2C9extracellular space

11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP2C8, CYP2C9extracellular space

14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPL, CYP2C8, CYP2C9extracellular space

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

triacylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
unspecific monooxygenase (arachidonate)

Catalysed by LPL, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes