N-acetyl-L-aspartate

Three steps

• 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosolOne of 3 routes

• 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosol

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosol

• 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosol

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosol

• 16alpha,17alpha-dihydroxyprogesteroneReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ASPA, ACY3, CYP17A1cytosol, endoplasmic reticulum

• dodecanedioyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by ASPA, ACY3, NAT8Lcytosol, mitochondrial matrixOne of 4 routes

• decanedioyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by ASPA, ACY3, NAT8L, CPT1A and 2 morecytosol, mitochondrial matrixOne of 4 routes

• octanedioyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of Suberylcarnitine

  Catalysed by ASPA, ACY3, NAT8L, CPT1A and 2 morecytosol, mitochondrial matrixOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ASPA, ACY3, NAT8Lcytosol, mitochondrial matrixOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosol

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ASPA, ACY3, NAT8L, CPT1A and 2 morecytosol, mitochondrial matrix

• (13Z)-eicosenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ASPA, ACY3, NAT8L, CRAT and 1 morecytosol, mitochondrial matrix, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ASPA, ACY3, NAT8L, ACAA1 and 3 morecytosol, mitochondrial matrix, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ASPA, ACY3, NAT8L, CPT1A and 2 morecytosol, mitochondrial matrixOne of 2 routes

• pristanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2cytosol, mitochondrial matrixOne of 2 routes

• 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosol

• undecanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ASPA, ACY3, NAT8L, ACSM4 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• 1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosol

• 1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosolOne of 8 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ASPA, ACY3, NAT8L, ACADM and 3 morecytosol, mitochondrial matrix

• N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)

  Catalysed by ASPA, ACY3, ASAH1, CERKcytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ASPA, ACY3, NAT8L, HADHA and 2 morecytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ASPA, ACY3, SLC7A13, GLYATL1B and 1 morecytosol, inner side of the membrane, outer side of the membrane

• (7Z)-hexadecenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 4 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space, mitochondrial matrix