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Reach

arachidonoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

783 compounds within 3 steps: 5 in 1, 199 in 2, 579 in 3

Does it reach a compound?

Two steps

a 3-oxoacyl-CoAReach from here →
1. acyl-CoA pool formation and breakdown
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
Catalysed by ACAA1, SCP2, ACAA2, HADHBcytosol
(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. Arachidonyl-CoA hydrolase
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Arachidonyl-CoA hydrolase
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol
5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. Arachidonyl-CoA hydrolase
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

Three steps

N(omega)-methyl-L-arginineReach from here →
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes
(5E)-tetradecenoyl-(R)-carnitineReach from here →

Page 5 of 16

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 more

cytosol, endoplasmic reticulum

One of 7 routes

S-butanoyl-4'-phosphopantetheineReach from here →

Arachidonyl-CoA hydrolase
Butanoate:CoA ligase (AMP-forming)
butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

S-octanoyl-4'-phosphopantetheineReach from here →

Arachidonyl-CoA hydrolase
Octanoyl-CoA:L-carnitine O-octanoyltransferase
octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix

decanoyl-4'-phosphopantetheineReach from here →

Arachidonyl-CoA hydrolase
medium-chain acyl-CoA ligase (decanoic acid)
decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosol

S-dodecanoyl-4'-phosphopantetheineReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (lauric acid)
dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol

tetradecanoyl-4'-phosphopantetheineReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (myristic acid)
tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol

tauroursodeoxycholateReach from here →

Arachidonyl-CoA hydrolase
transport of arachidonate (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, extracellular spaceOne of 6 routes

glycoursodeoxycholateReach from here →

Arachidonyl-CoA hydrolase
transport of arachidonate (cytosol to extracellular)
transport of glycoursodeoxycholate (cytosol to extracellular)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, extracellular spaceOne of 6 routes

(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

Arachidonyl-CoA hydrolase
(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol

N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycineReach from here →

Arachidonyl-CoA hydrolase
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol

N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycineReach from here →

Arachidonyl-CoA hydrolase
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Arachidonyl-CoA hydrolase
arachidonate:oxygen 15-oxidoreductase
palmitoyl-CoA hydrolase (15(S)-HPETE)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoateReach from here →

Arachidonyl-CoA hydrolase
(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Arachidonyl-CoA hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
glutathione transferase (GSH)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 22 morecytosol, extracellular spaceOne of 4 routes

prostaglandin E3Reach from here →

Arachidonyl-CoA hydrolase
transport of arachidonate (cytosol to extracellular)
transport of prostaglandin E3 (cytosol to extracellular)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 4 routes

prostaglandin A2Reach from here →

Arachidonyl-CoA hydrolase
transport of arachidonate (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 4 routes

prostaglandin B1Reach from here →

Arachidonyl-CoA hydrolase
transport of arachidonate (cytosol to extracellular)
transport of prostaglandin B1 (cytosol to extracellular)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 4 routes

1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →

Arachidonyl-CoA hydrolase
(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosol

leukotriene F4Reach from here →

Arachidonyl-CoA hydrolase
transport of arachidonate (cytosol to extracellular)
transport of leukotriene F4 (cytosol to extracellular)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 5 routes

N-(9Z-octadecenoyl)glycineReach from here →

Arachidonyl-CoA hydrolase
glycine N-acyltransferase (N-arachidonoylglycine)
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix

N-octadecanoylglycineReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (stearate)
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 2 routes

N-(9Z-hexadecenoyl)-glycineReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (palmitolate)
(9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes

8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
unspecific monooxygenase (arachidonate)
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 28 morecytosol

11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol

14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
unspecific monooxygenase (arachidonate)
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 32 morecytosol

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
unspecific monooxygenase (arachidonate)
5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 28 morecytosol

2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerolReach from here →

Arachidonyl-CoA hydrolase
fatty acid amide hydrolase (2-arachidonoylglycerol)
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

Arachidonyl-CoA hydrolase
(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol

(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Arachidonyl-CoA hydrolase
(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

2-hydroxyoctanoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
Octanoyl-CoA:L-carnitine O-octanoyltransferase
octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, mitochondrial matrix

2-hydroxydecanoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
medium-chain acyl-CoA ligase (decanoic acid)
decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosol

2-hydroxyeicosanoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (eicosanoate)
eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

2-hydroxydodecanoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (lauric acid)
dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

2-hydroxytetradecanoyl-CoAReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (myristic acid)
tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

11-cis-retinyl tetradecanoateReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (myristic acid)
11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes

9-cis-retinyl tetradecanoateReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (myristic acid)
9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

13-cis-retinyl tetradecanoateReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (myristic acid)
13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

all-trans-retinyl tetradecanoateReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (myristic acid)
all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

tetradecyl tetradecanoateReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (myristic acid)
tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (DHA)
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

N-hexadecanoylglycineReach from here →

Arachidonyl-CoA hydrolase
glycine N-acyltransferase (N-arachidonoylglycine)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix

N-dodecanoylglycineReach from here →

Arachidonyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (lauric acid)
dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes

N-decanoylglycineReach from here →

Arachidonyl-CoA hydrolase
medium-chain acyl-CoA ligase (decanoic acid)
decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosolOne of 2 routes

N-octanoylglycineReach from here →

Arachidonyl-CoA hydrolase
Octanoyl-CoA:L-carnitine O-octanoyltransferase
octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, mitochondrial matrixOne of 2 routes

N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

Arachidonyl-CoA hydrolase
glycine N-acyltransferase (N-arachidonoylglycine)
5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix