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N(2)-(1-hydroxy-2-oxopropyl)-dGTP

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

17 compounds within 3 steps: 2 in 1, 7 in 2, 8 in 3

Does it reach a compound?

One step

lactateReach from here →
1. N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
Catalysed by PARK7
dGTPReach from here →
1. N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
Catalysed by PARK7

Two steps

N(2)-(1-hydroxy-2-oxopropyl)-GTPReach from here →
1. N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
2. N(2)-(1-hydroxy-2-oxopropyl)-GTP + H2O = lactate + GTP + H(+)
Catalysed by PARK7
N(2)-(1-hydroxy-2-oxoethyl)-dGTPReach from here →
1. N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
2. N(2)-(1-hydroxy-2-oxoethyl)-dGTP + H2O = dGTP + glycolate + H(+)
Catalysed by PARK7
N(2)-(1-hydroxy-2-oxopropyl)-GDPReach from here →
1. N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)

Three steps

CHEBI:16174Reach from here →
Catalysed by PARK7, NUDT15mitochondrial matrix
guanineReach from here →
Catalysed by PARK7, SAMHD1, PNP

N(2)-(1-hydroxy-2-oxopropyl)-GDP + H2O = lactate + GDP + H(+)

Catalysed by PARK7

N(2)-(1-hydroxy-2-oxopropyl)-GMPReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
N(2)-(1-hydroxy-2-oxopropyl)-GMP + H2O = lactate + GMP + H(+)

Catalysed by PARK7

2'-deoxyguanosineReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)

Catalysed by PARK7, SAMHD1

triphosphateReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)

Catalysed by PARK7, SAMHD1

dGMPReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = dGMP + diphosphate + H(+)

Catalysed by PARK7, NUDT15

cytosol

One of 2 routes

inosineReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)
dGMP + inosine = 2'-deoxyguanosine + IMP

Catalysed by PARK7, SAMHD1, NT5C2

CHEBI:28862Reach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = dGMP + diphosphate + H(+)
ATP:dGMP phosphotransferase

Catalysed by PARK7, NUDT15, GUK1cytosolOne of 2 routes

glycolateReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
N(2)-(1-hydroxy-2-oxoethyl)-dGTP + H2O = dGTP + glycolate + H(+)
N(2)-(1-hydroxy-2-oxoethyl)-dGTP + H2O = dGTP + glycolate + H(+)

Catalysed by PARK7

2-deoxy-alpha-D-ribose 1-phosphateReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)
2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine

Catalysed by PARK7, SAMHD1, PNP

IMPReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = dGMP + diphosphate + H(+)
dGMP + inosine = 2'-deoxyguanosine + IMP

Catalysed by PARK7, NUDT15, NT5C2

7,8-dihydroneopterin 3'-triphosphateReach from here →

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)
dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate + H(+)

Catalysed by PARK7, SAMHD1, PTS