Pathway
The activation of arylsulfatases
Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation.
REACT:R-HSA-1663150Reactome
What the reference databases state
Statements
13 statements
13 statements · 1 reference database · Subject: The activation of arylsulfatases · Sources: Reactome
- ARSA participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSB participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSD participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSF participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSG participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSH participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSI participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSJ participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSK participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- ARSL participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- STS participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
- SUMF1 participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only
Show the remaining 1
- SUMF2 participates in The activation of arylsulfatasesProteinReactome R-HSA-1663150Inferred only