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Proteins/UNIPROT:O75747

PIK3C2G

Protein·UNIPROT:O75747Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Open in the graph

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity). May play a role in SDF1A-stimulated chemotaxis (By similarity)..

Function from UniProtKB (O75747), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

36 statements

36 statements · 5 reference databases · Subject: PIK3C2G · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

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ARID4A covaries with PIK3C2GProteinHetionet hetionet:covaries:5288-5926Inferred only
MAP3K19 covaries with PIK3C2GProteinHetionet hetionet:covaries:5288-80122Inferred only
PCNX4 covaries with PIK3C2GProteinHetionet hetionet:covaries:5288-64430Inferred only
POLK covaries with PIK3C2GProteinHetionet hetionet:covaries:51426-5288Inferred only
SYNE2 covaries with PIK3C2GProteinHetionet hetionet:covaries:23224-5288Inferred only
TOP6BL covaries with PIK3C2GProteinHetionet hetionet:covaries:5288-79703Inferred only
ZNF197 covaries with PIK3C2GProteinHetionet hetionet:covaries:10168-5288Inferred only
PIK3C2G participates in AKT signaling and ARTD family membersPathwayWikiPathways WP5531Inferred only
PIK3C2G participates in Angiopoietin like protein 8 regulatory pathwayPathwayWikiPathways WP3915Inferred only
PIK3C2G participates in Cyclin dependent kinase 4 6 inhibitors in breast cancerPathwayWikiPathways WP5497Inferred only
PIK3C2G participates in DNA damage response only ATM dependent PathwayWikiPathways WP710Inferred only
PIK3C2G participates in Effect of omega 3 PUFA on Huntington 39 s disease pathwaysPathwayWikiPathways WP5470Inferred only

Show the remaining 24

PIK3C2G participates in Glioblastoma signalingPathwayWikiPathways WP2261Inferred only
PIK3C2G participates in Insulin signalingPathwayWikiPathways WP481Inferred only
PIK3C2G participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PIK3C2G participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
PIK3C2G participates in Osteoblast differentiation and related diseasesPathwayWikiPathways WP4787Inferred only
PIK3C2G participates in Phosphatidyl inositol phosphate pathwayPathwayWikiPathways WP5411Inferred only
PIK3C2G participates in Phosphoinositide 3 kinase PI3K familyPathwayWikiPathways WP5472Inferred only
PIK3C2G participates in Phosphoinositides metabolismPathwayWikiPathways WP4971Inferred only
PIK3C2G participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
PIK3C2G participates in PI MetabolismPathwayReactome R-HSA-1483255Inferred only
PIK3C2G participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
PIK3C2G participates in Synthesis of PIPs at the Golgi membranePathwayReactome R-HSA-1660514Inferred only
PIK3C2G participates in Synthesis of PIPs at the plasma membranePathwayReactome R-HSA-1660499Inferred only
PIK3C2G participates in Targeted therapy in breast cancerPathwayWikiPathways WP5496Inferred only
PIK3C2G decreases the expression of ABL1ProteinHetionet hetionet:regulates:5288-25Inferred only
PIK3C2G decreases the expression of BPHLProteinHetionet hetionet:regulates:5288-670Inferred only
PIK3C2G decreases the expression of ISOC1ProteinHetionet hetionet:regulates:5288-51015Inferred only
1-phosphatidyl-1D-myo-inositol is a substrate of PIK3C2GCompoundHuman-GEM MAR08827Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) is a substrate of PIK3C2GCompoundRhea RHEA:18373Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) is a substrate of PIK3C2GCompoundHuman-GEM MAR08819Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) is a substrate of PIK3C2GCompoundHuman-GEM MAR06548Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) is a substrate of PIK3C2GCompoundHuman-GEM MAR03313Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) is a substrate of PIK3C2GCompoundHuman-GEM MAR08825Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) is a substrate of PIK3C2GCompoundRhea RHEA:12709Inferred only

Reactions

7 reactions

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATPADP+proton+MAM02735n
Catalysed by PIK3C2A & PIK3C2B or PIK3C2G
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.137nucleus
Human-GEM MAR03313CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ATPMAM00551c+ADP+

Other names

3 names

Resolves to: PIK3C2G

Also called: Phosphoinositide 3-kinase-C2-gammaPI3K-C2-gammaPtdIns-3-kinase C2 subunit gamma

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Catalysed by PIK3C2A & PIK3C2B or PIK3C2G or PIK3R5

Reaction pageLeft to rightBalance undeterminableEC 2.7.1.154cytosol

Human-GEM MAR06548CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ATPMAM00551n+ADP+proton

Catalysed by PIK3C2A & PIK3C2B or PIK3C2G

Reaction pageLeft to rightBalance undeterminableEC 2.7.1.154nucleus

Human-GEM MAR08819CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATPADP+proton+MAM02735r

Catalysed by PIK3C2A & PIK3C2B or PIK3C2G

Reaction pageLeft to rightBalance undeterminableEC 2.7.1.154endoplasmic reticulum

Human-GEM MAR08825CC BY 4.0Reference data

ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+ADP+proton

Catalysed by PIK3C2A & PIK3C2B or PIK3C2G

Reaction pageLeft to rightBalance undeterminableEC 2.7.1.154endoplasmic reticulum

Human-GEM MAR08827CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+ATP(4-)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+ADP(3-)+hydron

Catalysed by PIK3CD or PIK3C2A or PIK3C2B or PIK3C2G or PIK3CA or PIK3CG or PIK3C3

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:12709CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ATP(4-)CHEBI:57658+ADP(3-)+hydron

Catalysed by PIK3C2A or PIK3C2B or PIK3C2G or PIK3CG

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:18373CC BY 4.0Reference data