Proteins/UNIPROT:Q9BRT9

GINS4

ProteinUNIPROT:Q9BRT9

Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built..

Function from UniProtKB (Q9BRT9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 2 reference databases · Subject: GINS4 · Sources: Hetionet, Reactome

Order

CDC45 interacts with GINS4ProteinHetionet hetionet:interacts:8318-84296Inferred only
GINS1 interacts with GINS4ProteinHetionet hetionet:interacts:84296-9837Inferred only
GINS2 interacts with GINS4ProteinHetionet hetionet:interacts:51659-84296Inferred only
GINS3 interacts with GINS4ProteinHetionet hetionet:interacts:64785-84296Inferred only
GRK5 interacts with GINS4ProteinHetionet hetionet:interacts:2869-84296Inferred only
POLA1 interacts with GINS4ProteinHetionet hetionet:interacts:5422-84296Inferred only
POLD1 interacts with GINS4ProteinHetionet hetionet:interacts:5424-84296Inferred only
POLE interacts with GINS4ProteinHetionet hetionet:interacts:5426-84296Inferred only
UBC interacts with GINS4ProteinHetionet hetionet:interacts:7316-84296Inferred only
GINS4 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
GINS4 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
GINS4 participates in DNA ReplicationPathwayReactome R-HSA-69306Inferred only

Show the remaining 4

GINS4 participates in DNA strand elongationPathwayReactome R-HSA-69190Inferred only
GINS4 participates in S PhasePathwayReactome R-HSA-69242Inferred only
GINS4 participates in Synthesis of DNAPathwayReactome R-HSA-69239Inferred only
GINS4 participates in Unwinding of DNAPathwayReactome R-HSA-176974Inferred only

Other names

3 names

Resolves to: GINS4

Also called: DNA replication complex GINS protein SLD5GINS complex subunit 4SLD5

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