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Proteins/UNIPROT:Q8IUK8
Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long-term maintenance but not establishment of excitatory synapses. Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response..
Function from UniProtKB (Q8IUK8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
107 statements
107 statements · 1 reference database · Subject: CBLN2 · Sources: Hetionet
1 name
Resolves to: CBLN2