Loading the page.
Proteins/UNIPROT:Q9H9B1
Histone methyltransferase that specifically mono-, di- and trimethylates 'Lys-9' of histone H3 (H3K9me1, H3K9me2 and H3K9me3, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently (By similarity). Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. Involved in the differentiation of myoblastic precursors into brown adipose cells: following recruitment to chromatin by PRDM16, mediates formation of H3K9me2 and H3K9me3, inhibiting the expression of white adipose-selective genes (By similarity). Also involved in the differentiation of beige adipocytes from white adipose cells following recruitment by PRDM16 (By similarity). EHMT1 also promotes protein stabilization of PRDM16, by preventing PRDM16 ubiquitination and degradation (By similarity). In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity)..
Function from UniProtKB (Q9H9B1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
48 statements
48 statements · 5 reference databases · Subject: EHMT1 · Sources: Bgee, gene ontology, Hetionet, Reactome, WikiPathways
10 reactions
11 names
Resolves to: EHMT1
Reaction pageReversibleBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR04241CC BY 4.0Reference data
MAM00204c+S-adenosyl-L-methionineMAM00213c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06975CC BY 4.0Reference data
MAM00213c+S-adenosyl-L-methionineMAM00212c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06976CC BY 4.0Reference data
MAM00212c+S-adenosyl-L-methionineMAM00211c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06977CC BY 4.0Reference data
MAM00204n+S-adenosyl-L-methionineproton+MAM02129n+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08025CC BY 4.0Reference data
MAM02129n+S-adenosyl-L-methionineMAM00212n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08026CC BY 4.0Reference data
MAM00212n+S-adenosyl-L-methionineMAM00211n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08027CC BY 4.0Reference data
L-lysyl(9)-[histone H3]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl(9)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by MECOM or SETDB1 or EHMT2 or SETD5 or EHMT1 or PRDM16 or ASH1L
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60280CC BY 4.0Reference data
N(6)-methyl-L-lysyl(9)-[histone H3]+S-adenosyl-L-methionineN(6),N(6)-dimethyl-L-lysyl(9)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by SUV39H1 or EHMT2 or SUV39H2 or EHMT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60284CC BY 4.0Reference data
N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3]+S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by SUV39H1 or SETDB1 or SETDB2 or SUV39H2 or EHMT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60288CC BY 4.0Reference data