Pathway
Regulation of PTEN gene transcription
Transcription of the PTEN gene is regulated at multiple levels. Epigenetic repression involves the recruitment of Mi-2/NuRD upon SALL4 binding to the PTEN promoter or EVI1-mediated recruitment of the polycomb repressor complex (PRC) to the PTEN promoter. Transcriptional regulation is also elicited by negative regulators, including NR2E1:ATN1 (atrophin-1) complex, JUN (c-Jun), SNAIL and SLUG and positive regulators such as TP53 (p53), MAF1, ATF2, EGR1 or PPARG.
REACT:R-HSA-8943724Reactome
What the reference databases state
Statements
59 statements
59 statements · 1 reference database · Subject: Regulation of PTEN gene transcription · Sources: Reactome
- ATF2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- ATN1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- BMI1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- CBX2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- CBX4 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- CBX6 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- CBX8 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- CHD3 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- CHD4 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- EED participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- EGR1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- EZH2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
Show the remaining 47
- GATAD2A participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- GATAD2B participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- HDAC1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- HDAC2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- HDAC3 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- HDAC5 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- HDAC7 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- JUN participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- KDM1A participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- LAMTOR1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- LAMTOR2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- LAMTOR3 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- LAMTOR4 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- LAMTOR5 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MAF1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MAPK1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MAPK3 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MBD3 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MECOM participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MLST8 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MTA1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MTA2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MTA3 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- MTOR participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- NR2E1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- PHC1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- PHC2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- PHC3 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- PPARG participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RBBP4 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RBBP7 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RCOR1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- REST participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RHEB participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RING1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RNF2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RPTOR participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RRAGA participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RRAGB participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RRAGC participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- RRAGD participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- SALL4 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- SLC38A9 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- SNAI1 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- SNAI2 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- SUZ12 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only
- TP53 participates in Regulation of PTEN gene transcriptionProteinReactome R-HSA-8943724Inferred only