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Proteins/UNIPROT:Q9C0A6
Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion..
Function from UniProtKB (Q9C0A6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
89 statements
89 statements · 4 reference databases · Subject: SETD5 · Sources: Bgee, gene ontology, Hetionet, WikiPathways
2 reactions
L-lysyl(9)-[histone H3]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl(9)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by MECOM or SETDB1 or EHMT2 or SETD5 or EHMT1 or PRDM16 or ASH1L
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60280CC BY 4.0Reference data
L-lysyl(36)-[histone H3]+3S-adenosyl-L-methionine
2 names
Resolves to: SETD5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60324CC BY 4.0Reference data