Pathway
Nuclear Envelope Breakdown
The nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelope from chromatin. NEBD allows mitotic spindle microtubules to access condensed chromosomes at kinetochores and enables nuclear division and segregation of genetic material to two daughter cells. For a recent review, please refer to Guttinger et al. 2009.
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In mitotic prophase, chromatin detaches from the nuclear envelope, and this contributes to the nuclear envelope breakdown. VRK1 (and possibly VRK2) mediated phosphorylation of BANF1 (BAF), a protein that simultaneously interacts with DNA, LEM-domain inner nuclear membrane proteins, and lamins is considered to be one of the key steps in the detachment of the nuclear envelope from chromatin.
REACT:R-HSA-2980766Reactome
What the reference databases state
Statements
46 statements
46 statements · 1 reference database · Subject: Nuclear Envelope Breakdown · Sources: Reactome
- AAAS participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- BANF1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- CCNB1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- CCNB2 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- CDK1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- CNEP1R1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- CTDNEP1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- EMD participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- LEMD2 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- LEMD3 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- LMNB1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- LPIN1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
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- LPIN2 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- LPIN3 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NDC1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NEK6 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NEK7 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NEK9 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP107 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP133 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP153 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP155 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP160 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP188 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP205 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP210 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP214 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP35 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP37 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP42 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP43 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP50 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP54 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP62 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP85 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP88 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- NUP93 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- PLK1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- POM121 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- PRKCA participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- PRKCB participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- RAE1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- RANBP2 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- SEC13 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- TPR participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only
- VRK1 participates in Nuclear Envelope BreakdownProteinReactome R-HSA-2980766Inferred only