Proteins/UNIPROT:P40225

THPO

ProteinUNIPROT:P40225

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets..

Function from UniProtKB (P40225), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

amegakaryocytic thrombocytopenia, congenital, 2 has a germline basis in THPODiseaseGenCC HGNC:11795|MONDO:0957575Inferred only
familial thrombocytosis has a germline basis in THPODiseaseGenCC HGNC:11795|MONDO:0019111Inferred only
hereditary thrombocytosis with transverse limb defect has a germline basis in THPODiseaseGenCC HGNC:11795|MONDO:0018000Inferred only
thrombocythemia 1 has a germline basis in THPODiseaseGenCC HGNC:11795|MONDO:0008554Inferred only
thrombocytopenia 9 has a germline basis in THPODiseaseGenCC HGNC:11795|MONDO:0957572Inferred only

Statements

38 statements

38 statements · 3 reference databases · Subject: THPO · Sources: gene ontology, Hetionet, Reactome

Order

THPO covaries with ADAMTSL5ProteinHetionet hetionet:covaries:339366-7066Inferred only
THPO covaries with FAM227BProteinHetionet hetionet:covaries:196951-7066Inferred only
FANCG covaries with THPOProteinHetionet hetionet:covaries:2189-7066Inferred only
FBXL6 covaries with THPOProteinHetionet hetionet:covaries:26233-7066Inferred only
THPO covaries with HSD3B7ProteinHetionet hetionet:covaries:7066-80270Inferred only
THPO covaries with IL17RBProteinHetionet hetionet:covaries:55540-7066Inferred only
THPO covaries with ITM2CProteinHetionet hetionet:covaries:7066-81618Inferred only
THPO covaries with LRRC32ProteinHetionet hetionet:covaries:2615-7066Inferred only
THPO covaries with LZTS3ProteinHetionet hetionet:covaries:7066-9762Inferred only
THPO covaries with MAST2ProteinHetionet hetionet:covaries:23139-7066Inferred only
THPO covaries with MRPL37ProteinHetionet hetionet:covaries:51253-7066Inferred only
THPO covaries with MSANTD4ProteinHetionet hetionet:covaries:7066-84437Inferred only

Show the remaining 26

NCBP3 covaries with THPOProteinHetionet hetionet:covaries:55421-7066Inferred only
NCKAP5L covaries with THPOProteinHetionet hetionet:covaries:57701-7066Inferred only
THPO covaries with NYNRINProteinHetionet hetionet:covaries:57523-7066Inferred only
THPO covaries with RBM15ProteinHetionet hetionet:covaries:64783-7066Inferred only
THPO covaries with SNAI1ProteinHetionet hetionet:covaries:6615-7066Inferred only
THPO covaries with SPTBN2ProteinHetionet hetionet:covaries:6712-7066Inferred only
THPO covaries with SUN2ProteinHetionet hetionet:covaries:25777-7066Inferred only
THPO covaries with TUT4ProteinHetionet hetionet:covaries:23318-7066Inferred only
THPO covaries with ZFP90ProteinHetionet hetionet:covaries:146198-7066Inferred only
THPO covaries with ZNF646ProteinHetionet hetionet:covaries:7066-9726Inferred only
ZSCAN21 covaries with THPOProteinHetionet hetionet:covaries:7066-7589Inferred only
THPO interacts with APH1AProteinHetionet hetionet:interacts:51107-7066Inferred only
EP300 interacts with THPOProteinHetionet hetionet:interacts:2033-7066Inferred only
MPL interacts with THPOProteinHetionet hetionet:interacts:4352-7066Inferred only
THPO interacts with NUMBLProteinHetionet hetionet:interacts:7066-9253Inferred only
THPO participates in HemostasisPathwayReactome R-HSA-109582Inferred only
THPO participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
THPO participates in Platelet Aggregation (Plug Formation)PathwayReactome R-HSA-76009Inferred only
THPO regulates positive regulation of cell population proliferationBiological processgene ontology P40225|GO:0008284Inferred only
THPO regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology P40225|GO:0070374Inferred only
THPO regulates positive regulation of hematopoietic stem cell proliferationBiological processgene ontology P40225|GO:1902035Inferred only
THPO regulates positive regulation of MAPK cascadeBiological processgene ontology P40225|GO:0043410Inferred only
THPO regulates positive regulation of megakaryocyte differentiationBiological processgene ontology P40225|GO:0045654Inferred only
THPO regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology P40225|GO:0051897Inferred only
THPO regulates positive regulation of protein phosphorylationBiological processgene ontology P40225|GO:0001934Inferred only
THPO regulates regulation of hemopoiesisBiological processgene ontology P40225|GO:1903706Inferred only

Other names

6 names

Resolves to: THPO

Also called: C-mpl ligandMegakaryocyte colony-stimulating factorMegakaryocyte growth and development factorMGDFMLMyeloproliferative leukemia virus oncogene ligand

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