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Proteins/UNIPROT:P22083
[Isoform Short]: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE..
[Isoform Long]: Does not generate Lewis X antigens..
Function from UniProtKB (P22083), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 6 reference databases · Subject: FUT4 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
17 reactions
MAM01950c+a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))GDP+proton+MAM02199c
Catalysed by FUT9 or FUT7 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.-cytosol
Human-GEM MAR00878CC BY 4.0Reference data
MAM01950c+MAM02196cGDP+proton+MAM02162c
Catalysed by FUT9
10 names
Resolves to: FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.-cytosol
Human-GEM MAR00882CC BY 4.0Reference data
MAM01950c+a neolactoside nLc4Cer(d18:1(4E))GDP+proton+MAM02163c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00888CC BY 4.0Reference data
MAM01950c+MAM02596cMAM01885c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00893CC BY 4.0Reference data
MAM01885c+MAM01950cMAM01886c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00894CC BY 4.0Reference data
MAM01886c+MAM01950cMAM01887c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00895CC BY 4.0Reference data
MAM01950c+MAM02594cGDP+proton+MAM03133c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00896CC BY 4.0Reference data
MAM01950c+MAM03133cGDP+proton+MAM03132c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00897CC BY 4.0Reference data
MAM01950c+MAM03137cMAM01882c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00899CC BY 4.0Reference data
MAM01882c+MAM01950cMAM01883c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00900CC BY 4.0Reference data
MAM01950c+MAM02594cGDP+proton+MAM02164c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00911CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694g+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or POMGNT1 or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 16 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00925CC BY 4.0Reference data