Proteins/UNIPROT:Q11128

FUT5

ProteinUNIPROT:Q111284-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5

Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosaccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates in the surface expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens. Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate. Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosaccharide via an alpha (1,4) linkage. Preferentially catalyzes sialylated type 2 oligosaccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosaccharide acceptors. Lactose-based structures are also acceptor substrates..

Function from UniProtKB (Q11128), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

30 statements

30 statements · 4 reference databases · Subject: FUT5 · Sources: Human-GEM, Reactome, Rhea, WikiPathways

Order

FUT5 participates in Blood group systems biosynthesisPathwayReactome R-HSA-9033658Inferred only
FUT5 participates in Lewis blood group biosynthesisPathwayReactome R-HSA-9037629Inferred only
FUT5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
FUT5 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
FUT5 participates in Neolacto series sphingolipid metabolismPathwayWikiPathways WP5302Inferred only
a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) is a substrate of FUT5CompoundHuman-GEM MAR00863Inferred only
a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of FUT5CompoundRhea RHEA:23628Inferred only
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of FUT5CompoundRhea RHEA:14257Inferred only
a neolactoside nLc4Cer is a substrate of FUT5CompoundRhea RHEA:48376Inferred only
a neolactoside nLc4Cer(d18:1(4E)) is a substrate of FUT5CompoundRhea RHEA:48332Inferred only
a neolactoside nLc4Cer(d18:1(4E)) is a substrate of FUT5CompoundHuman-GEM MAR00888Inferred only
a neolactoside nLc6Cer is a substrate of FUT5CompoundRhea RHEA:48364Inferred only

Show the remaining 18

a neolactoside nLc6Cer(d18:1(4E)) is a substrate of FUT5CompoundRhea RHEA:48336Inferred only
alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine is a substrate of FUT5CompoundHuman-GEM MAR00871Inferred only
an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative is a substrate of FUT5CompoundRhea RHEA:62904Inferred only
an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of FUT5CompoundRhea RHEA:56076Inferred only
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine is a substrate of FUT5CompoundRhea RHEA:62824Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:62904Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:14257Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:23628Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:48332Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:48336Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:48352Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:48364Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:48376Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:52864Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:56076Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:62824Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:62836Inferred only
GDP-beta-L-fucose is a substrate of FUT5CompoundRhea RHEA:62900Inferred only

Reactions

30 reactions

MAM00808c+MAM01950cMAM01849c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol
Human-GEM MAR00862CC BY 4.0Reference data
MAM01950c+a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))MAM01860c+GDP+proton
Catalysed by

Other names

6 names

Resolves to: FUT5

Also called: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5Fuc-TVFucosyltransferase 5Fucosyltransferase VFucT-VGalactoside 3-L-fucosyltransferase

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FUT5

or FUT6

or FUT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol

Human-GEM MAR00863CC BY 4.0Reference data

MAM01950c+MAM03090cMAM01850c+GDP+proton

Catalysed by FUT5 or FUT6 or FUT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol

Human-GEM MAR00870CC BY 4.0Reference data

MAM01950c+alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineGDP+proton+MAM02194c

Catalysed by FUT5 or FUT6 or FUT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol

Human-GEM MAR00871CC BY 4.0Reference data

MAM01874c+GDP+protonMAM01950c+MAM03091c

Catalysed by FUT5 or FUT3

Reaction pageReversibleBalance undeterminableEC 2.4.1.65cytosol

Human-GEM MAR00873CC BY 4.0Reference data

MAM01950c+a neolactoside nLc4Cer(d18:1(4E))GDP+proton+MAM02163c

Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4