Proteins/UNIPROT:P51993

FUT6

ProteinUNIPROT:P519934-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6

[Isoform 1]: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants. Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants. Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X. Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates..

[Isoform 2]: Does not have alpha(1,3)-fucosyltransferase activity..

Function from UniProtKB (P51993), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

29 statements

29 statements · 4 reference databases · Subject: FUT6 · Sources: Bgee, Human-GEM, Reactome, Rhea

Order

FUT6 is expressed in buccal mucosa cellCell typeBgee ENSG00000156413Inferred only
FUT6 is expressed in ileal mucosaAnatomyBgee ENSG00000156413Inferred only
FUT6 is expressed in nasal cavity epitheliumAnatomyBgee ENSG00000156413Inferred only
FUT6 is expressed in pancreatic ductal cellCell typeBgee ENSG00000156413Inferred only
FUT6 is expressed in pharyngeal mucosaAnatomyBgee ENSG00000156413Inferred only
FUT6 participates in Blood group systems biosynthesisPathwayReactome R-HSA-9033658Inferred only
FUT6 participates in Lewis blood group biosynthesisPathwayReactome R-HSA-9037629Inferred only
FUT6 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
FUT6 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) is a substrate of FUT6CompoundHuman-GEM MAR00863Inferred only
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of FUT6CompoundRhea RHEA:14257Inferred only
a neolactoside nLc4Cer(d18:1(4E)) is a substrate of FUT6CompoundHuman-GEM MAR00888Inferred only

Show the remaining 17

a neolactoside nLc6Cer is a substrate of FUT6CompoundRhea RHEA:48364Inferred only
a neolactoside nLc6Cer is a substrate of FUT6CompoundRhea RHEA:48368Inferred only
alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine is a substrate of FUT6CompoundHuman-GEM MAR00871Inferred only
an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of FUT6CompoundRhea RHEA:56076Inferred only
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine is a substrate of FUT6CompoundRhea RHEA:62824Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:64032Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:14257Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:48356Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:48364Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:48368Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:52864Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:56076Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:62824Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:62836Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:62888Inferred only
GDP-beta-L-fucose is a substrate of FUT6CompoundRhea RHEA:64016Inferred only
lactose is a substrate of FUT6CompoundRhea RHEA:62888Inferred only

Reactions

27 reactions

MAM00808c+MAM01950cMAM01849c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol
Human-GEM MAR00862CC BY 4.0Reference data
MAM01950c+a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))MAM01860c+GDP+proton
Catalysed by

Other names

6 names

Resolves to: FUT6

Also called: FCT3AFuc-TVIFucosyltransferase 6Fucosyltransferase VIFucT-VIGalactoside 3-L-fucosyltransferase

← Every protein Find it in the graph →

FUT5

or FUT6

or FUT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol

Human-GEM MAR00863CC BY 4.0Reference data

MAM01950c+MAM03090cMAM01850c+GDP+proton

Catalysed by FUT5 or FUT6 or FUT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol

Human-GEM MAR00870CC BY 4.0Reference data

MAM01950c+alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineGDP+proton+MAM02194c

Catalysed by FUT5 or FUT6 or FUT3

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.65cytosol

Human-GEM MAR00871CC BY 4.0Reference data

MAM01950c+a neolactoside nLc4Cer(d18:1(4E))GDP+proton+MAM02163c

Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4