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Proteins/UNIPROT:Q9Y231
Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation. Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Can also modify milk oligosaccharides, in particular type 2 tetrasaccharide LNnT..
Function from UniProtKB (Q9Y231), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 5 reference databases · Subject: FUT9 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea
32 reactions
MAM01950c+a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))GDP+proton+MAM02199c
Catalysed by FUT9 or FUT7 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.-cytosol
Human-GEM MAR00878CC BY 4.0Reference data
MAM01950c+MAM02196cGDP+proton+MAM02162c
Catalysed by FUT9
5 names
Resolves to: FUT9
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.-cytosol
Human-GEM MAR00882CC BY 4.0Reference data
MAM01950c+a neolactoside nLc4Cer(d18:1(4E))GDP+proton+MAM02163c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00888CC BY 4.0Reference data
MAM01950c+MAM02596cMAM01885c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00893CC BY 4.0Reference data
MAM01885c+MAM01950cMAM01886c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00894CC BY 4.0Reference data
MAM01886c+MAM01950cMAM01887c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00895CC BY 4.0Reference data
MAM01950c+MAM02594cGDP+proton+MAM03133c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00896CC BY 4.0Reference data
MAM01950c+MAM03133cGDP+proton+MAM03132c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00897CC BY 4.0Reference data
MAM01950c+MAM03137cMAM01882c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00899CC BY 4.0Reference data
MAM01882c+MAM01950cMAM01883c+GDP+proton
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00900CC BY 4.0Reference data
MAM01950c+MAM02594cGDP+proton+MAM02164c
Catalysed by FUT5 or FUT6 or FUT3 or FUT9 or FUT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.152, 2.4.1.65, 2.4.1.-cytosol
Human-GEM MAR00911CC BY 4.0Reference data
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00926CC BY 4.0Reference data