Proteins/UNIPROT:O95243

MBD4

ProteinUNIPROT:O95243

Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein..

Function from UniProtKB (O95243), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

tumor predisposition syndrome 2 has a germline basis in MBD4DiseaseGenCC HGNC:6919|MONDO:0859267Inferred only
uveal melanoma has a germline basis in MBD4DiseaseGenCC HGNC:6919|MONDO:0006486Inferred only

Statements

27 statements

27 statements · 3 reference databases · Subject: MBD4 · Sources: Hetionet, Reactome, WikiPathways

Order

DCHS2 covaries with MBD4ProteinHetionet hetionet:covaries:54798-8930Inferred only
MBD4 covaries with GALNT15ProteinHetionet hetionet:covaries:117248-8930Inferred only
MDC1 covaries with MBD4ProteinHetionet hetionet:covaries:8930-9656Inferred only
MBD4 interacts with CDCA2ProteinHetionet hetionet:interacts:157313-8930Inferred only
CSNK2B interacts with MBD4ProteinHetionet hetionet:interacts:1460-8930Inferred only
DNMT3B interacts with MBD4ProteinHetionet hetionet:interacts:1789-8930Inferred only
FADD interacts with MBD4ProteinHetionet hetionet:interacts:8772-8930Inferred only
FAS interacts with MBD4ProteinHetionet hetionet:interacts:355-8930Inferred only
HDAC1 interacts with MBD4ProteinHetionet hetionet:interacts:3065-8930Inferred only
HTT interacts with MBD4ProteinHetionet hetionet:interacts:3064-8930Inferred only
MLH1 interacts with MBD4ProteinHetionet hetionet:interacts:4292-8930Inferred only
MBD4 interacts with SIN3AProteinHetionet hetionet:interacts:25942-8930Inferred only

Show the remaining 15

SUMO2 interacts with MBD4ProteinHetionet hetionet:interacts:6613-8930Inferred only
TRIM27 interacts with MBD4ProteinHetionet hetionet:interacts:5987-8930Inferred only
UBC interacts with MBD4ProteinHetionet hetionet:interacts:7316-8930Inferred only
MBD4 participates in Base excision repairPathwayWikiPathways WP4752Inferred only
MBD4 participates in Base Excision RepairPathwayReactome R-HSA-73884Inferred only
MBD4 participates in Base-Excision Repair, AP Site FormationPathwayReactome R-HSA-73929Inferred only
MBD4 participates in Cleavage of the damaged pyrimidinePathwayReactome R-HSA-110329Inferred only
MBD4 participates in DepyrimidinationPathwayReactome R-HSA-73928Inferred only
MBD4 participates in Displacement of DNA glycosylase by APEX1PathwayReactome R-HSA-110357Inferred only
MBD4 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
MBD4 participates in Genes and complexes involved in the DNA repair pathwaysPathwayWikiPathways WP4946Inferred only
MBD4 participates in Recognition and association of DNA glycosylase with site containing an affected pyrimidinePathwayReactome R-HSA-110328Inferred only
MBD4 participates in Resolution of Abasic Sites (AP sites)PathwayReactome R-HSA-73933Inferred only
EGR1 increases the expression of MBD4ProteinHetionet hetionet:regulates:1958-8930Inferred only
ZIM3 increases the expression of MBD4ProteinHetionet hetionet:regulates:114026-8930Inferred only

Other names

4 names

Resolves to: MBD4

Also called: MED1Methyl-CpG-binding endonuclease 1Methyl-CpG-binding protein MBD4Mismatch-specific DNA N-glycosylase

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