Proteins/UNIPROT:P58340

MLF1

ProteinUNIPROT:P58340

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus..

Function from UniProtKB (P58340), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 2 reference databases · Subject: MLF1 · Sources: gene ontology, Hetionet

Order

CEBPD interacts with MLF1ProteinHetionet hetionet:interacts:1052-4291Inferred only
MLF1 interacts with CENPUProteinHetionet hetionet:interacts:4291-79682Inferred only
MLF1 interacts with COPS3ProteinHetionet hetionet:interacts:4291-8533Inferred only
MLF1 interacts with DNAJB6ProteinHetionet hetionet:interacts:10049-4291Inferred only
GRIK5 interacts with MLF1ProteinHetionet hetionet:interacts:2901-4291Inferred only
MAGEA11 interacts with MLF1ProteinHetionet hetionet:interacts:4110-4291Inferred only
MLF1 interacts with NRBP1ProteinHetionet hetionet:interacts:29959-4291Inferred only
MLF1 interacts with UBCProteinHetionet hetionet:interacts:4291-7316Inferred only
MLF1 interacts with YWHAZProteinHetionet hetionet:interacts:4291-7534Inferred only
MLF1 regulates regulation of cell cycle G1/S phase transitionBiological processgene ontology P58340|GO:1902806Inferred only
MLF1 regulates regulation of DNA-templated transcriptionBiological processgene ontology P58340|GO:0006355Inferred only
MLF1 regulates regulation of signal transduction by p53 class mediatorBiological processgene ontology P58340|GO:1901796Inferred only

Show the remaining 4

FOXJ1 increases the expression of MLF1ProteinHetionet hetionet:regulates:2302-4291Inferred only
GTF2E2 decreases the expression of MLF1ProteinHetionet hetionet:regulates:2961-4291Inferred only
MAPK9 increases the expression of MLF1ProteinHetionet hetionet:regulates:5601-4291Inferred only
XRCC5 increases the expression of MLF1ProteinHetionet hetionet:regulates:7520-4291Inferred only

Other names

2 names

Resolves to: MLF1

Also called: Myelodysplasia-myeloid leukemia factor 1Myeloid leukemia factor 1

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