Proteins/UNIPROT:O15230

LAMA5

ProteinUNIPROT:O15230

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2..

Function from UniProtKB (O15230), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

LAMA5-related multisystemic syndrome has a germline basis in LAMA5DiseaseGenCC HGNC:6485|MONDO:0033856Inferred only
nephrotic syndrome, IIa 26 has a germline basis in LAMA5DiseaseGenCC HGNC:6485|MONDO:0031061Inferred only

Statements

68 statements

68 statements · 4 reference databases · Subject: LAMA5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

LAMA5 covaries with BAHCC1ProteinHetionet hetionet:covaries:3911-57597Inferred only
DGKQ covaries with LAMA5ProteinHetionet hetionet:covaries:1609-3911Inferred only
GATA5 covaries with LAMA5ProteinHetionet hetionet:covaries:140628-3911Inferred only
LAMA5 covaries with SDF4ProteinHetionet hetionet:covaries:3911-51150Inferred only
LAMA5 covaries with TMED2ProteinHetionet hetionet:covaries:10959-3911Inferred only
ZDHHC7 covaries with LAMA5ProteinHetionet hetionet:covaries:3911-55625Inferred only
LAMA5 interacts with ATF7IPProteinHetionet hetionet:interacts:3911-55729Inferred only
LAMA5 interacts with BCAMProteinHetionet hetionet:interacts:3911-4059Inferred only
LAMA5 interacts with BTBD10ProteinHetionet hetionet:interacts:3911-84280Inferred only
COL7A1 interacts with LAMA5ProteinHetionet hetionet:interacts:1294-3911Inferred only
CRKL interacts with LAMA5ProteinHetionet hetionet:interacts:1399-3911Inferred only
DAG1 interacts with LAMA5ProteinHetionet hetionet:interacts:1605-3911Inferred only

Show the remaining 56

FBLN2 interacts with LAMA5ProteinHetionet hetionet:interacts:2199-3911Inferred only
GZMB interacts with LAMA5ProteinHetionet hetionet:interacts:3002-3911Inferred only
LAMA5 interacts with LAMC1ProteinHetionet hetionet:interacts:3911-3915Inferred only
LAMA5 interacts with MEP1AProteinHetionet hetionet:interacts:3911-4224Inferred only
LAMA5 interacts with MUC7ProteinHetionet hetionet:interacts:3911-4589Inferred only
LAMA5 interacts with MYOCProteinHetionet hetionet:interacts:3911-4653Inferred only
LAMA5 interacts with PLATProteinHetionet hetionet:interacts:3911-5327Inferred only
LAMA5 interacts with PLGProteinHetionet hetionet:interacts:3911-5340Inferred only
LAMA5 interacts with SMAD2ProteinHetionet hetionet:interacts:3911-4087Inferred only
LAMA5 interacts with SV2AProteinHetionet hetionet:interacts:3911-9900Inferred only
LAMA5 interacts with UBCProteinHetionet hetionet:interacts:3911-7316Inferred only
LAMA5 interacts with USP4ProteinHetionet hetionet:interacts:3911-7375Inferred only
LAMA5 participates in Alpha 6 beta 4 signalingPathwayWikiPathways WP244Inferred only
LAMA5 participates in Attachment of bacteria to epithelial cellsPathwayReactome R-HSA-9638630Inferred only
LAMA5 participates in Bacterial Infection PathwaysPathwayReactome R-HSA-9824439Inferred only
LAMA5 participates in Biofilm formationPathwayReactome R-HSA-9931953Inferred only
LAMA5 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
LAMA5 participates in Complement systemPathwayWikiPathways WP2806Inferred only
LAMA5 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
LAMA5 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
LAMA5 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
LAMA5 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
LAMA5 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
LAMA5 participates in Developmental Lineage of Pancreatic Ductal CellsPathwayReactome R-HSA-9925563Inferred only
LAMA5 participates in Developmental Lineage of Pancreatic Endocrine Mid Progenitor CellsPathwayReactome R-HSA-9981148Inferred only
LAMA5 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
LAMA5 participates in ECM proteoglycansPathwayReactome R-HSA-3000178Inferred only
LAMA5 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
LAMA5 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
LAMA5 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
LAMA5 participates in Formation of the dystrophin-glycoprotein complex (DGC)PathwayReactome R-HSA-9913351Inferred only
LAMA5 participates in Hair follicle development organogenesis stage 2 of 3PathwayWikiPathways WP2839Inferred only
LAMA5 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
LAMA5 participates in Infection with EnterobacteriaPathwayReactome R-HSA-9640148Inferred only
LAMA5 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
LAMA5 participates in Inflammatory response pathwayPathwayWikiPathways WP453Inferred only
LAMA5 participates in Interleukin-4 and Interleukin-13 signalingPathwayReactome R-HSA-6785807Inferred only
LAMA5 participates in Laminin interactionsPathwayReactome R-HSA-3000157Inferred only
LAMA5 participates in MET activates PTK2 signalingPathwayReactome R-HSA-8874081Inferred only
LAMA5 participates in MET promotes cell motilityPathwayReactome R-HSA-8875878Inferred only
LAMA5 participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
LAMA5 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
LAMA5 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
LAMA5 participates in Primary focal segmental glomerulosclerosis FSGS PathwayWikiPathways WP2572Inferred only
LAMA5 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
LAMA5 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
LAMA5 participates in Signaling by METPathwayReactome R-HSA-6806834Inferred only
LAMA5 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
LAMA5 participates in Small cell lung cancerPathwayWikiPathways WP4658Inferred only
LAMA5 regulates regulation of cell adhesionBiological processgene ontology O15230|GO:0030155Inferred only
LAMA5 regulates regulation of cell migrationBiological processgene ontology O15230|GO:0030334Inferred only
LAMA5 regulates regulation of embryonic developmentBiological processgene ontology O15230|GO:0045995Inferred only
ALDOC increases the expression of LAMA5ProteinHetionet hetionet:regulates:230-3911Inferred only
CLTB increases the expression of LAMA5ProteinHetionet hetionet:regulates:1212-3911Inferred only
EPHA2 decreases the expression of LAMA5ProteinHetionet hetionet:regulates:1969-3911Inferred only
ETV1 increases the expression of LAMA5ProteinHetionet hetionet:regulates:2115-3911Inferred only

Other names

5 names

Resolves to: LAMA5

Also called: KIAA0533KIAA1907Laminin-10 subunit alphaLaminin-11 subunit alphaLaminin-15 subunit alpha

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