Proteins/UNIPROT:Q9ULM3

YEATS2

ProteinUNIPROT:Q9ULM3

Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors..

Function from UniProtKB (Q9ULM3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

benign adult familial myoclonic epilepsy has a germline basis in YEATS2DiseaseGenCC HGNC:25489|MONDO:0019448Inferred only

Statements

30 statements

30 statements · 3 reference databases · Subject: YEATS2 · Sources: gene ontology, Hetionet, Reactome

Order

YEATS2 covaries with CERS1ProteinHetionet hetionet:covaries:10715-55689Inferred only
N4BP2L2 covaries with YEATS2ProteinHetionet hetionet:covaries:10443-55689Inferred only
ZNF177 covaries with YEATS2ProteinHetionet hetionet:covaries:55689-7730Inferred only
RAD21 interacts with YEATS2ProteinHetionet hetionet:interacts:55689-5885Inferred only
SUMO2 interacts with YEATS2ProteinHetionet hetionet:interacts:55689-6613Inferred only
UBC interacts with YEATS2ProteinHetionet hetionet:interacts:55689-7316Inferred only
YEATS2 participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
YEATS2 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
YEATS2 participates in Epigenetic regulation by WDR5-containing histone modifying complexesPathwayReactome R-HSA-9917777Inferred only
YEATS2 participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
YEATS2 participates in Formation of WDR5-containing histone-modifying complexesPathwayReactome R-HSA-9772755Inferred only
YEATS2 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only

Show the remaining 18

YEATS2 participates in HATs acetylate histonesPathwayReactome R-HSA-3214847Inferred only
YEATS2 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9ULM3|GO:0000122Inferred only
YEATS2 regulates regulation of cell cycleBiological processgene ontology Q9ULM3|GO:0051726Inferred only
YEATS2 regulates regulation of cell divisionBiological processgene ontology Q9ULM3|GO:0051302Inferred only
YEATS2 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q9ULM3|GO:0006355Inferred only
YEATS2 regulates regulation of embryonic developmentBiological processgene ontology Q9ULM3|GO:0045995Inferred only
YEATS2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9ULM3|GO:0006357Inferred only
YEATS2 regulates regulation of tubulin deacetylationBiological processgene ontology Q9ULM3|GO:0090043Inferred only
AKR1A1 increases the expression of YEATS2ProteinHetionet hetionet:regulates:10327-55689Inferred only
GBP2 increases the expression of YEATS2ProteinHetionet hetionet:regulates:2634-55689Inferred only
MAST4 decreases the expression of YEATS2ProteinHetionet hetionet:regulates:375449-55689Inferred only
PAF1 increases the expression of YEATS2ProteinHetionet hetionet:regulates:54623-55689Inferred only
PAN2 increases the expression of YEATS2ProteinHetionet hetionet:regulates:9924-55689Inferred only
PARP2 decreases the expression of YEATS2ProteinHetionet hetionet:regulates:10038-55689Inferred only
PLOD3 decreases the expression of YEATS2ProteinHetionet hetionet:regulates:8985-55689Inferred only
SMARCA4 decreases the expression of YEATS2ProteinHetionet hetionet:regulates:6597-55689Inferred only
TLE1 increases the expression of YEATS2ProteinHetionet hetionet:regulates:7088-55689Inferred only
TNFRSF21 increases the expression of YEATS2ProteinHetionet hetionet:regulates:27242-55689Inferred only

Other names

2 names

Resolves to: YEATS2

Also called: KIAA1197YEATS domain-containing protein 2

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