Pathway
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
The transcriptional activity of the RUNX1:CBFB complex is regulated by interaction with co-factors and posttranslational modifications of RUNX1. Protein serine/threonine kinase HIPK2 can phosphorylate RUNX1 and affect transcriptional activity of the RUNX1:CBFB complex during hematopoiesis. Some CBFB mutations found in leukemia interfere with HIPK2-mediated phosphorylation of RUNX1. HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300) bound to the RUNX1:CBFB1 complex.
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The RUNX1:CBFB complex can associate with the polycomb repressor complex 1 (PRC1). PRC1 complexes are found at many RUNX1 target promoters and can act either as co-activators or co-repressors in the transactivation of RUNX1 targets.
RUNX1 recruits the SWI/SNF chromatin remodeling complex to many RUNX1 target promoters by directly interacting with several SWI/SNF subunits.
Other co-factors of the RUNX1:CBFB complex are annotated in the context of transcriptional regulation of specific genes.
REACT:R-HSA-8939243Reactome
What the reference databases state
Statements
36 statements
36 statements · 1 reference database · Subject: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known · Sources: Reactome
- ACTL6A participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- ACTL6B participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- ARID1A participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- ARID1B participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- ARID2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- AUTS2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- BMI1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- CBFB participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- CBX2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- CBX4 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- CBX6 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- CBX8 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
Show the remaining 24
- CSNK2A1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- CSNK2A2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- CSNK2B participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- EP300 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- HIPK2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- PBRM1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- PCGF5 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- PHC1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- PHC2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- PHC3 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- RING1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- RNF2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- RUNX1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- RYBP participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCA2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCA4 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCB1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCC1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCC2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCD1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCD2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCD3 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- SMARCE1 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only
- YAF2 participates in RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownProteinReactome R-HSA-8939243Inferred only