Compound
12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
A HETE anion that is the conjugate base of 12-HETE arising from deprotonation of the carboxylic acid function; major species at pH 7.3.
Definition from ChEBI (CHEBI:90718), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound, anion
- Formula
- C20H31O3
- Mass
- 319.465 g/mol
- Charge
- -1
- InChIKey
- ZNHVWPKMFKADKW-VXBMJZGYSA-M
- SMILES
- CCCCC/C=CCC(O)/C=C/C=CC/C=CCCCC(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
Reactions
3 reactions
12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:90719+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4F2 or CYP4F3 or CYP4F11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48664CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+reduced [NADPH--hemoprotein reductase]+dioxygen12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate+oxidized [NADPH--hemoprotein reductase]+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:51484CC BY 4.0Reference data
12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate+ATP(4-)+coenzyme A(4-)12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSL4 or ACSL3 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52112CC BY 4.0Reference data
Other names
5 names
Resolves to: 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
- Also called
- (5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoate12-HETE12-hydroxy-(5Z,8Z,10E,14Z)-icosatetraenoate12H-(5Z,8Z,10E,14Z)-ETE
- Systematic name
- (5Z,8Z,10E,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoate